A0A2K5VR43 · A0A2K5VR43_MACFA
- ProteinCarbonyl reductase [NADPH] 1
- GeneCBR1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids415 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
- H+ + menadione + NADPH = menadiol + NADP+
- NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPHThis reaction proceeds in the forward direction.
- NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPHThis reaction proceeds in the forward direction.
- corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+This reaction proceeds in the forward direction.
- cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+This reaction proceeds in the forward direction.
- daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbonyl reductase (NADPH) activity | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Biological Process | epithelial cell differentiation | |
Biological Process | glucocorticoid metabolic process | |
Biological Process | positive regulation of reactive oxygen species metabolic process | |
Biological Process | vitamin K metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbonyl reductase [NADPH] 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5VR43
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 14-61 | Disordered | ||||
Sequence: ARVRPRSSASSSAKSGQLALRPRARSSASRFCKVRPAGSPPARHPGEV | ||||||
Compositional bias | 16-30 | Polar residues | ||||
Sequence: VRPRSSASSSAKSGQ |
Sequence similarities
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length415
- Mass (Da)45,083
- Last updated2021-06-02 v2
- ChecksumE7A29EF6DA31553D
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5VRD3 | A0A2K5VRD3_MACFA | CBR1 | 178 | ||
A0A2K5VR61 | A0A2K5VR61_MACFA | CBR1 | 171 | ||
A0A2K5VR85 | A0A2K5VR85_MACFA | CBR1 | 415 | ||
G7P114 | G7P114_MACFA | CBR1 | 391 | ||
A0A7N9CT50 | A0A7N9CT50_MACFA | CBR1 | 331 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 16-30 | Polar residues | ||||
Sequence: VRPRSSASSSAKSGQ |
Keywords
- Technical term