A0A2K5VR43 · A0A2K5VR43_MACFA

Function

Catalytic activity

  • H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
  • H+ + menadione + NADPH = menadiol + NADP+
  • NADP+ + prostaglandin D2 = 15-oxoprostaglandin D2 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E1 = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • NADP+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + prostaglandin F2alpha = H+ + NADPH + prostaglandin E2
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + H+ + NADPH
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + H+ + NADPH
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + H+ + NADPH = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + H+ + NADPH = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + H+ + NADPH = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbonyl reductase (NADPH) activity
Molecular Functionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Processepithelial cell differentiation
Biological Processglucocorticoid metabolic process
Biological Processpositive regulation of reactive oxygen species metabolic process
Biological Processvitamin K metabolic process
Biological Processxenobiotic metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase [NADPH] 1
  • EC number
  • Alternative names
    • 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
    • 20-beta-hydroxysteroid dehydrogenase
    • Alcohol dehydrogenase [NAD(P)+] CBR1
    • Prostaglandin 9-ketoreductase
    • Prostaglandin-E(2) 9-reductase

Gene names

    • Name
      CBR1

Organism names

Accessions

  • Primary accession
    A0A2K5VR43

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region14-61Disordered
Compositional bias16-30Polar residues

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    45,083
  • Last updated
    2021-06-02 v2
  • Checksum
    E7A29EF6DA31553D
MVLHCYVGSRQPAARVRPRSSASSSAKSGQLALRPRARSSASRFCKVRPAGSPPARHPGEVRVGRGRVVPLRPAPRPPLPARGGAWACACALSGRACNLRVGAPRPPDSRSLWDTRRASPGPEPGLFFTQVPRASHSAMKSGIRVALVTGGNKGIGLAIVRDLCRLFSGEVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRTLRDFLLKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNISSMMSLRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPSATKSPEEGAETPVYLALLPLDAEGPHGQFVMEKRVEQW

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5VRD3A0A2K5VRD3_MACFACBR1178
A0A2K5VR61A0A2K5VR61_MACFACBR1171
A0A2K5VR85A0A2K5VR85_MACFACBR1415
G7P114G7P114_MACFACBR1391
A0A7N9CT50A0A7N9CT50_MACFACBR1331

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias16-30Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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