A0A2K5TWQ4 · A0A2K5TWQ4_MACFA
- ProteinPhospholipid-transporting ATPase
- GeneATP9A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1169 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | late endosome | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | recycling endosome membrane | |
Cellular Component | trans-Golgi network membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATPase-coupled intramembrane lipid transporter activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | protease binding | |
Biological Process | endocytosis | |
Biological Process | negative regulation of exosomal secretion | |
Biological Process | phospholipid translocation | |
Biological Process | regulation of endocytic recycling | |
Biological Process | regulation of retrograde transport, endosome to Golgi | |
Biological Process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipid-transporting ATPase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5TWQ4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 420-444 | Helical | ||||
Sequence: LEVNCLTKILFGALVVVSLVMVALQ | ||||||
Transmembrane | 450-469 | Helical | ||||
Sequence: WYLQIIRFLLLFSNIIPISL | ||||||
Transmembrane | 968-988 | Helical | ||||
Sequence: VIHRSLCISTMQAVFSSVFYF | ||||||
Transmembrane | 994-1016 | Helical | ||||
Sequence: YQGFLIIGYSTIYTMFPVFSLVL | ||||||
Transmembrane | 1046-1066 | Helical | ||||
Sequence: FLIWVLISIYQGSTIMYGALL | ||||||
Transmembrane | 1072-1093 | Helical | ||||
Sequence: FVHIVAISFTSLILTELLMVAL | ||||||
Transmembrane | 1100-1120 | Helical | ||||
Sequence: WLMTVAELLSLACYIASLVFL | ||||||
Transmembrane | 1126-1152 | Helical | ||||
Sequence: VYFIATLSFLWKVSVITLVSCLPLYVL |
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-137 | Disordered | ||||
Sequence: MEWNVEGGTAARARGGGAVGGRGRRGHGGPAAPVAGAARSERAQRGARAHGAPVSVGRAARAAPRVARRSRARPSLRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKR | ||||||
Compositional bias | 64-84 | Basic residues | ||||
Sequence: PRVARRSRARPSLRARPARCR | ||||||
Domain | 168-228 | P-type ATPase N-terminal | ||||
Sequence: PEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYW | ||||||
Domain | 934-1161 | P-type ATPase C-terminal | ||||
Sequence: LAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVITLVSCLPLYVLKYLRRRFSP |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,169
- Mass (Da)130,113
- Last updated2021-06-02 v2
- Checksum6FC5C5B76BFAA557
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5TWR8 | A0A2K5TWR8_MACFA | ATP9A | 911 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 64-84 | Basic residues | ||||
Sequence: PRVARRSRARPSLRARPARCR |
Keywords
- Technical term