A0A2K5TV19 · A0A2K5TV19_MACFA

Function

function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsarcoplasmic reticulum membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioncalcium ion binding
Molecular FunctionP-type calcium transporter activity
Molecular Functionprotein homodimerization activity
Biological Processapoptotic mitochondrial changes
Biological Processcalcium ion import
Biological Processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Processmaintenance of mitochondrion location
Biological Processnegative regulation of endoplasmic reticulum calcium ion concentration
Biological Processpositive regulation of endoplasmic reticulum calcium ion concentration
Biological Processpositive regulation of fast-twitch skeletal muscle fiber contraction
Biological Processpositive regulation of mitochondrial calcium ion concentration
Biological Processrelaxation of skeletal muscle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-transporting ATPase
  • EC number

Gene names

    • Name
      ATP2A1

Organism names

Accessions

  • Primary accession
    A0A2K5TV19

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Sarcoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane85-103Helical
Transmembrane109-132Helical
Transmembrane285-305Helical
Transmembrane317-346Helical
Transmembrane785-806Helical
Transmembrane858-882Helical
Transmembrane956-975Helical

Keywords

Interaction

Subunit

Interacts with sarcolipin (SLN). Interacts with phospholamban (PLN). Interacts with myoregulin (MRLN). Interacts with DWORF. Interacts with VMP1.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain28-102Cation-transporting P-type ATPase N-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,038
  • Mass (Da)
    113,725
  • Last updated
    2021-06-02 v2
  • Checksum
    B180406F61BAA831
MSPFISPPKAWGISATPSAKQEGSAMEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGPNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKAVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMILDDSARFLEYETDLTFVGVVGMLDPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLPEQREACRRACCFARVEPSHKSKIVEYLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMYAEDGPHVNYSQLTHFMQCTEDNAHFEGVDCEVFEASEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYIDPLPMIFKLQALDLAHWLMVLKIHCHFQMSIHSPPPPPPFLPSLSPFPAPPCLVLVASCPLWP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5TV81A0A2K5TV81_MACFAATP2A1795
A0A2K5TV38A0A2K5TV38_MACFAATP2A1279

Keywords

Genome annotation databases

Similar Proteins

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