A0A2K5TV19 · A0A2K5TV19_MACFA
- ProteinCalcium-transporting ATPase
- GeneATP2A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1038 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Catalytic activity
- Ca2+(in) + ATP + H2O = Ca2+(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.Ca2+ (in)CHEBI:29108
+ CHEBI:30616 + CHEBI:15377 = Ca2+ (out)CHEBI:29108+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | sarcoplasmic reticulum membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | calcium ion binding | |
Molecular Function | P-type calcium transporter activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | apoptotic mitochondrial changes | |
Biological Process | calcium ion import | |
Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | maintenance of mitochondrion location | |
Biological Process | negative regulation of endoplasmic reticulum calcium ion concentration | |
Biological Process | positive regulation of endoplasmic reticulum calcium ion concentration | |
Biological Process | positive regulation of fast-twitch skeletal muscle fiber contraction | |
Biological Process | positive regulation of mitochondrial calcium ion concentration | |
Biological Process | relaxation of skeletal muscle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-transporting ATPase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5TV19
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Sarcoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 85-103 | Helical | ||||
Sequence: LLVRILLLAACISFVLAWF | ||||||
Transmembrane | 109-132 | Helical | ||||
Sequence: TITAFVEPFVILLILIANAIVGVW | ||||||
Transmembrane | 285-305 | Helical | ||||
Sequence: LSKVISLICVAVWLINIGHFN | ||||||
Transmembrane | 317-346 | Helical | ||||
Sequence: AIYYFKIAVALAVAAIPEGLPAVITTCLAL | ||||||
Transmembrane | 785-806 | Helical | ||||
Sequence: FIRYLISSNVGEVVCIFLTAAL | ||||||
Transmembrane | 858-882 | Helical | ||||
Sequence: LFFRYMAIGGYVGAATVGAAAWWFM | ||||||
Transmembrane | 956-975 | Helical | ||||
Sequence: IWLLGSICLSMSLHFLILYI |
Keywords
- Cellular component
Interaction
Subunit
Interacts with sarcolipin (SLN). Interacts with phospholamban (PLN). Interacts with myoregulin (MRLN). Interacts with DWORF. Interacts with VMP1.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-102 | Cation-transporting P-type ATPase N-terminal | ||||
Sequence: AAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGPNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAW |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,038
- Mass (Da)113,725
- Last updated2021-06-02 v2
- ChecksumB180406F61BAA831
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5TV81 | A0A2K5TV81_MACFA | ATP2A1 | 795 | ||
A0A2K5TV38 | A0A2K5TV38_MACFA | ATP2A1 | 279 |
Keywords
- Technical term