A0A2K5M7S9 · A0A2K5M7S9_CERAT
- Proteinnon-specific serine/threonine protein kinase
- GeneBRAF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids760 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | positive regulation of protein phosphorylation | |
Biological Process | protein modification process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Cercocebus
Accessions
- Primary accessionA0A2K5M7S9
Proteomes
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MAALSGGGGGGAEPGQALFNGDMEPEAGAAASSAAD | ||||||
Domain | 151-223 | RBD | ||||
Sequence: PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVL | ||||||
Domain | 230-276 | Phorbol-ester/DAG-type | ||||
Sequence: THNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMC | ||||||
Compositional bias | 304-333 | Polar residues | ||||
Sequence: AETALTSGSSPSAPTSDSLGPQILTSPSPS | ||||||
Region | 304-450 | Disordered | ||||
Sequence: AETALTSGSSPSAPTSDSLGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPD | ||||||
Compositional bias | 388-422 | Polar residues | ||||
Sequence: GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRER | ||||||
Compositional bias | 423-447 | Basic and acidic residues | ||||
Sequence: KSSSSSEDRNRMKTLGRRDSSDDWE | ||||||
Domain | 453-713 | Protein kinase | ||||
Sequence: ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length760
- Mass (Da)84,080
- Last updated2018-03-28 v1
- Checksum2D86E2C962A2CEBC
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5M7Q2 | A0A2K5M7Q2_CERAT | BRAF | 762 | ||
A0A2K5M7U5 | A0A2K5M7U5_CERAT | BRAF | 580 | ||
A0A2K5M7T5 | A0A2K5M7T5_CERAT | BRAF | 709 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 304-333 | Polar residues | ||||
Sequence: AETALTSGSSPSAPTSDSLGPQILTSPSPS | ||||||
Compositional bias | 388-422 | Polar residues | ||||
Sequence: GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRER | ||||||
Compositional bias | 423-447 | Basic and acidic residues | ||||
Sequence: KSSSSSEDRNRMKTLGRRDSSDDWE |
Keywords
- Technical term