A0A2K5KHL0 · A0A2K5KHL0_CERAT
- ProteinDelta(14)-sterol reductase TM7SF2
- GeneTM7SF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids391 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H+ + NADPH
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + H+ + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + H+ + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase TM7SF2
- EC number
- Short namesDelta-14-SR
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Cercocebus
Accessions
- Primary accessionA0A2K5KHL0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-79 | Helical | ||||
Sequence: PRALLLWLAWLGLQAALYLL | ||||||
Transmembrane | 100-123 | Helical | ||||
Sequence: INGFQALVLTALLVGLGVSAGLPL | ||||||
Transmembrane | 129-149 | Helical | ||||
Sequence: MLLPLAFVATLTAFIFSLFLY | ||||||
Transmembrane | 254-273 | Helical | ||||
Sequence: GFGFMLAFGDIAWVPFTYSL | ||||||
Transmembrane | 328-357 | Helical | ||||
Sequence: LIMALAWSLPCGVSHLLPYFYLLYFTALLV |
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)43,223
- Last updated2018-03-28 v1
- Checksum1CC16B828E2D9880
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5KHK1 | A0A2K5KHK1_CERAT | TM7SF2 | 418 | ||
A0A2K5KHL2 | A0A2K5KHL2_CERAT | TM7SF2 | 89 |
Keywords
- Technical term