A0A2K5KHL0 · A0A2K5KHL0_CERAT

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase TM7SF2
  • EC number
  • Short names
    Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Sterol C14-reductase
    • Transmembrane 7 superfamily member 2

Gene names

    • Name
      TM7SF2

Organism names

Accessions

  • Primary accession
    A0A2K5KHL0

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane60-79Helical
Transmembrane100-123Helical
Transmembrane129-149Helical
Transmembrane254-273Helical
Transmembrane328-357Helical

Keywords

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    391
  • Mass (Da)
    43,223
  • Last updated
    2018-03-28 v1
  • Checksum
    1CC16B828E2D9880
MAPPEGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEALWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGVSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGISGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLVKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAILTTMDITHDGFGFMLAFGDIAWVPFTYSLQAQFLLRHPQPLGLPMASAICLINGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIVPYIY

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5KHK1A0A2K5KHK1_CERATTM7SF2418
A0A2K5KHL2A0A2K5KHL2_CERATTM7SF289

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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