A0A2K5IY85 · A0A2K5IY85_COLAP
- ProteinEctonucleotide pyrophosphatase/phosphodiesterase family member 3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids661 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.
Catalytic activity
- ATP + H2O = AMP + diphosphate + H+This reaction proceeds in the forward direction.
- P1,P3-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H+This reaction proceeds in the forward direction.
- P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H+This reaction proceeds in the forward direction.
- P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H+
- P1,P5-bis(5'-adenosyl) pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP + 2 H+This reaction proceeds in the forward direction.
- UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | nucleoside triphosphate diphosphatase activity | |
Biological Process | nucleoside triphosphate catabolic process |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEctonucleotide pyrophosphatase/phosphodiesterase family member 3
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5IY85
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-44 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer and homodimer.
Structure
Sequence
- Sequence statusComplete
- Length661
- Mass (Da)75,546
- Last updated2018-03-28 v1
- Checksum948ADF1521793C01
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5IY75 | A0A2K5IY75_COLAP | 873 | |||
A0A2K5IYV2 | A0A2K5IYV2_COLAP | 855 |
Keywords
- Technical term