A0A2K5IY85 · A0A2K5IY85_COLAP

Function

function

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.

Catalytic activity

  • ATP + H2O = AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.9 (UniProtKB | ENZYME | Rhea)
  • CTP + H2O = CMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.9 (UniProtKB | ENZYME | Rhea)
  • GTP + H2O = GMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.9 (UniProtKB | ENZYME | Rhea)
  • P1,P3-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H+
    This reaction proceeds in the forward direction.
  • P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H+
    This reaction proceeds in the forward direction.
  • P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H+
  • P1,P5-bis(5'-adenosyl) pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP + 2 H+
    This reaction proceeds in the forward direction.
  • UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H+
    This reaction proceeds in the forward direction.
  • UTP + H2O = UMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.9 (UniProtKB | ENZYME | Rhea)
  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)
  • a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.9 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionnucleoside triphosphate diphosphatase activity
Biological Processnucleoside triphosphate catabolic process

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
  • EC number
  • Alternative names
    • Alkaline phosphodiesterase I
    • Dinucleoside polyphosphatase
    • Nucleotide diphosphatase
    • Nucleotide pyrophosphatase
    • Phosphodiesterase I beta
    • Phosphodiesterase I/nucleotide pyrophosphatase 3

Organism names

Accessions

  • Primary accession
    A0A2K5IY85

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-44Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Subunit

Monomer and homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-92SMB
Domain93-137SMB

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    661
  • Mass (Da)
    75,546
  • Last updated
    2018-03-28 v1
  • Checksum
    948ADF1521793C01
MESMLTLATEQPVKNTLKKYKIACIVLLALLVIVSLGLGLGLGLRKPEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWTCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLNTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKSFSLSSEDQNNEAWWHGQPMWLTAMYQGLKAATYFWPGSEVAKNGSFPSIYMPYNRSVPYEERISTLLKWLDLPKAERPSFYTMYFEEPDSSGHAAGPVSARVIKALQVVDSAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFYMYEGPAPRIRALNVPQDFFSFNSEEIVRNLSCRKSDQHFKPYLTPDLPKRLHYANNVRIDKVHLFVDRQWLAVRYKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEASKFSVCGFANPLPTDNLGCSCPHLQNSIQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKKVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQVPSIELLIANMML

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5IY75A0A2K5IY75_COLAP873
A0A2K5IYV2A0A2K5IYV2_COLAP855

Keywords

Genome annotation databases

Similar Proteins

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