A0A2K5IJW4 · A0A2K5IJW4_COLAP

Function

function

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.
    EC:3.4.14.9 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

156350100150200250300350400450500550
Type
IDPosition(s)Description
Active site272Charge relay system
Active site276Charge relay system
Active site475Charge relay system
Binding site517Ca2+ (UniProtKB | ChEBI)
Binding site518Ca2+ (UniProtKB | ChEBI)
Binding site541Ca2+ (UniProtKB | ChEBI)
Binding site543Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processcentral nervous system development
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tripeptidyl-peptidase 1
  • EC number
  • Alternative names
    • Tripeptidyl aminopeptidase
    • Tripeptidyl-peptidase I

Organism names

Accessions

  • Primary accession
    A0A2K5IJW4

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_501436867522-563Tripeptidyl-peptidase 1

Keywords

Interaction

Subunit

Monomer. Interacts with CLN5. Interacts with CLN3.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain199-563Peptidase S53

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    563
  • Mass (Da)
    61,279
  • Last updated
    2018-03-28 v1
  • Checksum
    AF4CAE9A18AEFF65
MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNLERLSELVQAVSDPNSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAQFHHYVGGPTETHVVRSPRPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVTRVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLILLSNESALPHVHTVSYGDEEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVAKFLSSSPHLPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGLLSLINEHRILSGRPPLGFLNPRLYHQHGAGLFDVTHGCHESCLDDEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5IKC8A0A2K5IKC8_COLAP450
A0A2K5IK61A0A2K5IK61_COLAP555

Keywords

Genome annotation databases

Similar Proteins

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