A0A2K5IJW4 · A0A2K5IJW4_COLAP
- ProteinTripeptidyl-peptidase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids563 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
Catalytic activity
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 272 | Charge relay system | |||
Active site | 276 | Charge relay system | |||
Active site | 475 | Charge relay system | |||
Binding site | 517 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 518 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 541 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 543 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | tripeptidyl-peptidase activity | |
Biological Process | central nervous system development | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTripeptidyl-peptidase 1
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5IJW4
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5014368675 | 22-563 | Tripeptidyl-peptidase 1 | ||
Keywords
- PTM
Interaction
Subunit
Monomer. Interacts with CLN5. Interacts with CLN3.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length563
- Mass (Da)61,279
- Last updated2018-03-28 v1
- ChecksumAF4CAE9A18AEFF65
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5IKC8 | A0A2K5IKC8_COLAP | 450 | |||
A0A2K5IK61 | A0A2K5IK61_COLAP | 555 |
Keywords
- Technical term