A0A2K5I938 · A0A2K5I938_COLAP
- ProteinVitamin K-dependent protein C
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids425 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 217 | Charge relay system | |||
Active site | 263 | Charge relay system | |||
Active site | 366 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum lumen | |
Cellular Component | extracellular space | |
Cellular Component | Golgi lumen | |
Molecular Function | calcium ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | blood coagulation | |
Biological Process | negative regulation of blood coagulation | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVitamin K-dependent protein C
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5I938
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5014383970 | 19-425 | Vitamin K-dependent protein C | ||
Disulfide bond | 101↔111 | ||||
Disulfide bond | 122↔131 | ||||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length425
- Mass (Da)48,208
- Last updated2018-03-28 v1
- Checksum302C48BA0AD8ECE3
Keywords
- Technical term