A0A2K5I938 · A0A2K5I938_COLAP

Function

function

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Degradation of blood coagulation factors Va and VIIIa.
    EC:3.4.21.69 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

142550100150200250300350400
TypeIDPosition(s)Description
Active site217Charge relay system
Active site263Charge relay system
Active site366Charge relay system

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum lumen
Cellular Componentextracellular space
Cellular ComponentGolgi lumen
Molecular Functioncalcium ion binding
Molecular Functionserine-type endopeptidase activity
Biological Processblood coagulation
Biological Processnegative regulation of blood coagulation
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Vitamin K-dependent protein C
  • EC number
  • Alternative names
    • Anticoagulant protein C
    • Autoprothrombin IIA
    • Blood coagulation factor XIV

Organism names

Accessions

  • Primary accession
    A0A2K5I938

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_501438397019-425Vitamin K-dependent protein C
Disulfide bond101↔111
Disulfide bond122↔131

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain42-88Gla
Domain97-132EGF-like
Region154-174Disordered
Domain176-414Peptidase S1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    425
  • Mass (Da)
    48,208
  • Last updated
    2018-03-28 v1
  • Checksum
    302C48BA0AD8ECE3
MWRLTSLLLFVATWGISSTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRPNSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCSSLCCGHGTCIDGIGSFSCDCRSGWEGRFCQRGEGERGKFPCGRPWRRIEKKRSHLKRRDTEDQEDQEDQVDPRLVDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMEESKKLLVRLGEYDLRRWEKWELDLDIEEVFIHPNYTKSTTDNDIALLRLAQPATLSQTIVPICLPDSGLAERKLTQAGQETLVTGWGYHSSREKEARRNRTFVLNFIKIPVVPRNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPAKGWAP

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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