A0A2K5I6P1 · A0A2K5I6P1_COLAP
- ProteinPeptide-methionine (R)-S-oxide reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids188 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
Catalytic activity
- [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:57844 + CHEBI:15377 = CHEBI:58773 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 zinc ion per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-methionine-(R)-S-oxide reductase activity | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide-methionine (R)-S-oxide reductase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5I6P1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-26 | ||||
Chain | PRO_5015797786 | 27-188 | Peptide-methionine (R)-S-oxide reductase | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-165 | MsrB | |||
Region | 165-188 | Disordered | |||
Sequence similarities
Belongs to the MsrB Met sulfoxide reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length188
- Mass (Da)20,243
- Last updated2018-03-28 v1
- MD5 Checksum36DD66A017983DFD1FD9CD0469D032BA
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5I6P0 | A0A2K5I6P0_COLAP | 185 | |||
A0A2K5I6Q1 | A0A2K5I6Q1_COLAP | 156 |
Keywords
- Technical term