A0A2K5I351 · A0A2K5I351_COLAP
- ProteinS-adenosylmethionine decarboxylase proenzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids334 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Catalytic activity
- S-adenosyl-L-methionine + H+ = S-adenosyl 3-(methylsulfanyl)propylamine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 7 | substrate | |||
Binding site | 67 | substrate | |||
Site | 67-68 | Cleavage (non-hydrolytic); by autolysis | |||
Active site | 68 | Schiff-base intermediate with substrate; via pyruvic acid | |||
Active site | 82 | Proton donor; for catalytic activity | |||
Binding site | 223 | substrate | |||
Active site | 229 | Proton acceptor; for processing activity | |||
Active site | 243 | Proton acceptor; for processing activity | |||
Binding site | 247 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylmethionine decarboxylase activity | |
Molecular Function | putrescine binding | |
Biological Process | spermidine biosynthetic process | |
Biological Process | spermine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine decarboxylase proenzyme
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5I351
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5042320508 | 1-67 | S-adenosylmethionine decarboxylase beta chain | ||
Modified residue | 68 | Pyruvic acid (Ser); by autocatalysis | |||
Chain | PRO_5042320509 | 68-334 | S-adenosylmethionine decarboxylase alpha chain | ||
Keywords
- PTM
Interaction
Structure
Sequence
- Sequence statusComplete
- Length334
- Mass (Da)38,320
- Last updated2018-03-28 v1
- Checksum4EB4765AF98E21BE
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5I364 | A0A2K5I364_COLAP | 214 | |||
A0A2K5I386 | A0A2K5I386_COLAP | 305 |
Keywords
- Technical term