A0A2K5I351 · A0A2K5I351_COLAP

Function

function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.

Catalytic activity

Cofactor

pyruvate (UniProtKB | Rhea| CHEBI:15361 )

Note: Binds 1 pyruvoyl group covalently per subunit.

Pathway

Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site7substrate
Binding site67substrate
Site67-68Cleavage (non-hydrolytic); by autolysis
Active site68Schiff-base intermediate with substrate; via pyruvic acid
Active site82Proton donor; for catalytic activity
Binding site223substrate
Active site229Proton acceptor; for processing activity
Active site243Proton acceptor; for processing activity
Binding site247substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionadenosylmethionine decarboxylase activity
Molecular Functionputrescine binding
Biological Processspermidine biosynthetic process
Biological Processspermine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine decarboxylase proenzyme
  • EC number

Organism names

Accessions

  • Primary accession
    A0A2K5I351

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_50423205081-67S-adenosylmethionine decarboxylase beta chain
Modified residue68Pyruvic acid (Ser); by autocatalysis
ChainPRO_504232050968-334S-adenosylmethionine decarboxylase alpha chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the eukaryotic AdoMetDC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    38,320
  • Last updated
    2018-03-28 v1
  • Checksum
    4EB4765AF98E21BE
MEAAHFFEGTEKLLEVWFSRQQPEANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVLTSFAKKQQQQQS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5I364A0A2K5I364_COLAP214
A0A2K5I386A0A2K5I386_COLAP305

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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