A0A2K5HJ26 · A0A2K5HJ26_COLAP

Function

function

Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionfructose 6-phosphate aldolase activity
Molecular Functionfructose-1-phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionprotein-glutamate O-methyltransferase activity
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    A0A2K5HJ26

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-237Damage-control phosphatase ARMT1-like metal-binding

Domain

Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    30,748
  • Last updated
    2018-03-28 v1
  • Checksum
    D852B71122B45E69
MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPIIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLFVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYESQESVIALCTHLQQLIKTIEDLDENQLKDEFFKLLQISLWGNKCDLSVSGGESSSQKTDVLNSLEDLKPFILLNDMEHLWSLLSNCKKTREKGCFCHHYNKLVLINSHSPFPHP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5HJ56A0A2K5HJ56_COLAP441

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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