A0A2K5HJ26 · A0A2K5HJ26_COLAP
- ProteinSugar phosphate phosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids264 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
Catalytic activity
- L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine
- beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate
- beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate
Cofactor
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | fructose 6-phosphate aldolase activity | |
Molecular Function | fructose-1-phosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein-glutamate O-methyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSugar phosphate phosphatase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Colobinae > Colobus
Accessions
- Primary accessionA0A2K5HJ26
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-237 | Damage-control phosphatase ARMT1-like metal-binding | ||||
Sequence: TIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPIIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLFVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYESQESVIALCTHLQQLIKTIEDLDENQLKDEFFKLLQISLWGNKCDLSVSGGESSSQKTDVLNSLEDLKPFILLNDMEHLWSLLSNCK |
Domain
Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length264
- Mass (Da)30,748
- Last updated2018-03-28 v1
- ChecksumD852B71122B45E69
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5HJ56 | A0A2K5HJ56_COLAP | 441 |
Keywords
- Technical term