A0A2K5HIK1 · A0A2K5HIK1_COLAP

Function

function

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCD40 receptor complex
Cellular Componentexternal side of plasma membrane
Molecular Functionantigen binding
Molecular Functionsignaling receptor activity
Biological ProcessB cell activation
Biological ProcessCD40 signaling pathway
Biological Processcellular response to interleukin-1
Biological Processcellular response to tumor necrosis factor
Biological Processdefense response to protozoan
Biological Processdefense response to virus
Biological Processimmune response-regulating cell surface receptor signaling pathway
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of B cell proliferation
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of endothelial cell apoptotic process
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of isotype switching to IgG isotypes
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processresponse to type II interferon
Biological ProcessTRIF-dependent toll-like receptor signaling pathway

Keywords

  • Molecular function
  • Biological process

Names & Taxonomy

Protein names

  • Recommended name
    Tumor necrosis factor receptor superfamily member 5
  • Alternative names
    • B-cell surface antigen CD40
    • CD40L receptor

Organism names

Accessions

  • Primary accession
    A0A2K5HIK1

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_501436110021-204Tumor necrosis factor receptor superfamily member 5
Disulfide bond38↔51
Disulfide bond41↔59
Disulfide bond62↔77
Disulfide bond125↔143

Keywords

Family & Domains

Features

Showing features for repeat, domain, region.

Type
IDPosition(s)Description
Repeat25-59TNFR-Cys
Domain25-59TNFR-Cys
Repeat61-103TNFR-Cys
Domain61-103TNFR-Cys
Repeat104-143TNFR-Cys
Domain104-143TNFR-Cys
Region166-204Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    22,282
  • Last updated
    2018-03-28 v1
  • Checksum
    1F621918FDB115DD
MVRLLLQCVLWGCLLTAVYPEPPTACREKQYLINSQCCSLCQPGQKLVSECTEFTETECLPCGESEFLDTWNRETRCHQHKYCDPNLGLRVQQKGTSKTDTTCTCEEGQHCTSEACESCVPHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCRPWTRSPGSAESPGGDPHLLGDPVCHPPLGAGLYQKGGQEAKR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5HIJ6A0A2K5HIJ6_COLAP278
A0A2K5HIP3A0A2K5HIP3_COLAP151

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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