A0A2K5HIJ0 · A0A2K5HIJ0_COLAP

Function

function

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site275-283ATP (UniProtKB | ChEBI)
Binding site302ATP (UniProtKB | ChEBI)
Active site404Proton acceptor

GO annotations

AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionactivin binding
Molecular Functionactivin receptor activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionSMAD binding
Molecular Functiontransforming growth factor beta binding
Molecular Functiontransforming growth factor beta receptor activity, type II
Molecular Functiontype I transforming growth factor beta receptor binding
Biological Processapoptotic process
Biological Processcell differentiation
Biological Processheart development
Biological Processprotein phosphorylation
Biological Processregulation of multicellular organismal process
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta receptor type-2
  • EC number
  • Short names
    TGFR-2
  • Alternative names
    • TGF-beta type II receptor
    • Transforming growth factor-beta receptor type II

Organism names

Accessions

  • Primary accession
    A0A2K5HIJ0

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane raft
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane185-214Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_501443949124-592TGF-beta receptor type-2
Disulfide bond76↔109
Disulfide bond79↔96
Disulfide bond86↔92
Disulfide bond102↔126
Disulfide bond146↔161
Disulfide bond163↔168

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain269-569Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    592
  • Mass (Da)
    67,345
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    3EAAC46EDD2F72A99EF74B3F37386BDF
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEARKGEMICPSCNRTAHPLRHINNDMMVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSSWEAGKARKLMDFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMASRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K5HIJ8A0A2K5HIJ8_COLAP567
A0A2K5HIN8A0A2K5HIN8_COLAP461
A0A2K5HIQ9A0A2K5HIQ9_COLAP328
A0A2K5HIP6A0A2K5HIP6_COLAP323

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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