A0A2K5F4L1 · A0A2K5F4L1_AOTNA
- ProteinL-selectin
- GeneSELL
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids385 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 131 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 133 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 139 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 156 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 157 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | oligosaccharide binding | |
Molecular Function | protease binding | |
Biological Process | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | |
Biological Process | leukocyte tethering or rolling |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameL-selectin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Aotidae > Aotus
Accessions
- Primary accessionA0A2K5F4L1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 347-368 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 70↔168 | ||||
Disulfide bond | 141↔160 | ||||
Disulfide bond | 173↔184 | ||||
Disulfide bond | 178↔193 | ||||
Disulfide bond | 195↔204 | ||||
Disulfide bond | 210↔254 | ||||
Disulfide bond | 240↔267 | ||||
Disulfide bond | 272↔316 | ||||
Disulfide bond | 302↔329 | ||||
Keywords
- PTM
Interaction
Subunit
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 47-169 | C-type lectin | |||
Domain | 169-205 | EGF-like | |||
Domain | 208-269 | Sushi | |||
Domain | 270-331 | Sushi | |||
Sequence similarities
Belongs to the selectin/LECAM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)43,255
- Last updated2018-03-28 v1
- ChecksumF2C82016E6D3E018
Keywords
- Technical term