A0A2K5DAB1 · A0A2K5DAB1_AOTNA

Function

function

Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation.

Catalytic activity

  • 2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • 2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward direction.
  • H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]
    This reaction proceeds in the forward direction.
    EC:3.1.2.22 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentlysosomal membrane
Cellular Componentperinuclear region of cytoplasm
Cellular Componentvacuolar lumen
Molecular Functionbis(monoacylglycero)phosphate synthase activity
Molecular FunctionD-mannose binding
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionlong-chain fatty acyl-CoA hydrolase activity
Biological Processbrain development
Biological Processglycosylation
Biological Processlysosomal lumen acidification
Biological Processneurogenesis
Biological Processretrograde transport, endosome to Golgi
Biological Processsignal peptide processing
Biological Processvisual perception

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bis(monoacylglycero)phosphate synthase CLN5
  • EC number
  • Alternative names
    • Ceroid-lipofuscinosis neuronal protein 5
    • Palmitoyl protein thioesterase CLN5
    • S-depalmitoylase CLN5

Gene names

    • Name
      CLN5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Aotidae > Aotus

Accessions

  • Primary accession
    A0A2K5DAB1

Proteomes

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-37Disordered

Sequence similarities

Belongs to the CLN5 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    397
  • Mass (Da)
    44,974
  • Last updated
    2018-03-28 v1
  • Checksum
    BDC1B865B3929ECF
GHGGLRPGLAAPRKLRPPASRGSGGAGSTGGSLMAPEGDTALGVVMRRSAGGARGRASRRWALALLCLAAAPGWLGASGSPSRRHWPEPYKRFDFRPKPDPYCQAKYTFCPTGSPIPVMKDDDDIEVFRLQTPVWEFKYGDLLGHLKIMHDAIGFRSTLTGKNYTVEWYELFQLGNCTFPHLRPEMDAPFWCNQGAACFFEGIDDAHWKENGTLVQVATISGNMFNKMAKWVKQDNETGIYYETWTVKASPEKGAETWFDSYDCSKFVLRTYNKLAEFGAEFKKIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLALAIKKFYYPFKPHLSTKEFLLSLLQIFDAVIVHRQFYLFYNFEYWFLPMKFPFIKITYEEIPLPNRNNTLSARRGSSHL

Keywords

Genome annotation databases

Similar Proteins

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