A0A2K5D4V3 · A0A2K5D4V3_AOTNA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    EC:3.1.1.32 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.34 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site136Nucleophile
Active site160Charge relay system
Binding site174Ca2+ (UniProtKB | ChEBI)
Binding site179Ca2+ (UniProtKB | ChEBI)
Active site245Charge relay system

GO annotations

AspectTerm
Cellular Componentcatalytic complex
Cellular Componentcell surface
Cellular Componentchylomicron
Cellular Componentplasma membrane
Cellular Componentvery-low-density lipoprotein particle
Molecular Function1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Functionapolipoprotein binding
Molecular Functioncalcium ion binding
Molecular Functionheparan sulfate proteoglycan binding
Molecular Functionheparin binding
Molecular Functionlipoprotein lipase activity
Molecular Functionlipoprotein particle binding
Molecular Functionphosphatidylserine 1-acylhydrolase activity
Molecular Functionphospholipase A1 activity
Molecular Functionprotein homodimerization activity
Molecular Functionsignaling receptor binding
Biological Processcellular response to fatty acid
Biological Processcellular response to nutrient
Biological Processcholesterol homeostasis
Biological Processchylomicron remodeling
Biological Processfatty acid biosynthetic process
Biological Processlow-density lipoprotein particle mediated signaling
Biological Processpositive regulation of adipose tissue development
Biological Processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Processpositive regulation of cholesterol storage
Biological Processpositive regulation of fat cell differentiation
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of macrophage derived foam cell differentiation
Biological Processpositive regulation of sequestering of triglyceride
Biological Processpositive regulation of tumor necrosis factor production
Biological Processresponse to bacterium
Biological Processtriglyceride catabolic process
Biological Processtriglyceride homeostasis
Biological Processvery-low-density lipoprotein particle remodeling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein lipase
  • EC number
  • Alternative names
    • Phospholipase A1

Gene names

    • Name
      LPL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Aotidae > Aotus

Accessions

  • Primary accession
    A0A2K5D4V3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501436858221-453Lipoprotein lipase

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain318-441PLAT

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    50,307
  • Last updated
    2018-03-28 v1
  • Checksum
    50D3B276F466636B
MESKALLLLALAVWLQSLTASRGGVAAADHRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTKTRLQPSLWLALAVHGTSATLAKCLSGYTKLVGDRDCEEFNYPLDSVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTKSETQTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWNSDSYFSWSDWWSSPGFAIEKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHAKSLNKKSGW

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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