A0A2K2HEB3 · A0A2K2HEB3_9BACT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

162150100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site193-200ATP (UniProtKB | ChEBI)
Binding site415Zn2+ (UniProtKB | ChEBI); catalytic
Active site416
Binding site419Zn2+ (UniProtKB | ChEBI); catalytic
Binding site491Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      C2E25_01530

Organism names

  • Taxonomic identifier
  • Strain
    • HR-1
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter

Accessions

  • Primary accession
    A0A2K2HEB3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-25Helical
Transmembrane100-121Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain185-324AAA+ ATPase
Region588-621Disordered
Compositional bias599-613Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    621
  • Mass (Da)
    68,494
  • Last updated
    2018-03-28 v1
  • Checksum
    54AC099BACDFE11E
MNQFYKNLALWLVISLVMILLFNMMTQHGQDQKPISYTAFLEAVNDGQVKEVTIQGPNLEGRYEDGKSFKTYIPDDPELIKDLRAKGVVIQARPEEDRSFWFTLLVSWGPILLLIGVWIFFMRQMQSGGGKAMSFGKSRAKLLNDGQARVTFKDVAGIDEAKDELEEIVAYLRDPKKFSRLGGRIPKGVLLVGAPGTGKTLLARAIAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFVQGKKQAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFESNEGVILIAATNRPDVLDPALLRPGRFDRQVVVPRPDIKGRLKILQVHARKVQMADNVDLETVARGTPGFSGADLANLVNEAALLAARADKNRVETEELEAAKDKVMMGAERRSMVITEDEKKVTAYHEAGHALVAQFIPGADPVHKVSIIPRGRAMGVTMYLPEEEKYNETKVGLHTKICTLLGGRVAEELTFDSVTSGAANDLERATAIARKMVCEWGMSDTLGPLTFGEKEGEVFLGRDMGHIKNYSEDTARQIDEEIQAIVTSNYQRTRQILEDHKAELNRVAEALLERENLDAGELKDLVFPAEQTPADRDSDRRAVPENAPEADPPES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias599-613Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PPFX01000002
EMBL· GenBank· DDBJ
PNU21571.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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