A0A2K2HA89 · A0A2K2HA89_9BACT
- ProteinGlutathione hydrolase proenzyme
- Geneggt
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids646 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 187 | L-glutamate (UniProtKB | ChEBI) | |||
Active site | 462 | Nucleophile | |||
Binding site | 480-482 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 504 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 533-534 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 555 | L-glutamate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione biosynthetic process | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase proenzyme
- EC number
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter
Accessions
- Primary accessionA0A2K2HA89
Proteomes
PTM/Processing
Post-translational modification
Cleaved by autocatalysis into a large and a small subunit.
Keywords
- PTM
Interaction
Subunit
This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length646
- Mass (Da)68,613
- Last updated2018-03-28 v1
- Checksum3A7AE37709C4220F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 56-71 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PPFX01000016 EMBL· GenBank· DDBJ | PNU20216.1 EMBL· GenBank· DDBJ | Genomic DNA |