A0A2K2H7G4 · A0A2K2H7G4_9BACT

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site21-23shikimate (UniProtKB | ChEBI)
Binding site68shikimate (UniProtKB | ChEBI)
Active site72Proton acceptor
Binding site93shikimate (UniProtKB | ChEBI)
Binding site108shikimate (UniProtKB | ChEBI)
Binding site157-162NADP+ (UniProtKB | ChEBI)
Binding site229NADP+ (UniProtKB | ChEBI)
Binding site231shikimate (UniProtKB | ChEBI)
Binding site252NADP+ (UniProtKB | ChEBI)
Binding site259shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      C2E25_13715

Organism names

  • Taxonomic identifier
  • Strain
    • HR-1
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Geothermobacteraceae > Geothermobacter

Accessions

  • Primary accession
    A0A2K2H7G4

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-95Shikimate dehydrogenase substrate binding N-terminal
Domain125-204Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain252-278SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    288
  • Mass (Da)
    30,328
  • Last updated
    2018-03-28 v1
  • Checksum
    31D6881021C9E8DD
MSGLTGKTRVLGIFGDPVSHSLSPAMQNAALQQAGVDAIYVPFHVTPEQLSRAVDGLRALQVWGVNVTIPHKEAICPLLDEVDADAALIGAVNTVVQRSGRLVGYNTDGDGLVASLQTDLQFDPRGRRILLLGAGGTSRSVAVALARAGAERITIANRTCSRARQLAADFTTVLPGTSFAAIGLEGSDLVVAVAECDLVVNSTSIGLQGEDFAGFPWQYLSSETRCYDIVYRRGGTPWLLRAGQQGCRCADGLGMLAAQGELAFRIWTGQSPPSGVMKCRLLAEVATS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PPFX01000037
EMBL· GenBank· DDBJ
PNU19199.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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