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A0A2K1QUC9 · A0A2K1QUC9_9PEZI

  • Protein
    Histone acetyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site1241Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionhistone H4K16 acetyltransferase activity
Molecular Functionpeptide 2-hydroxyisobutyryltransferase activity
Molecular Functionpeptide crotonyltransferase activity
Molecular Functiontranscription coregulator activity
Biological ProcessDNA repair
Biological Processnegative regulation of DNA-templated transcription
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone acetyltransferase
  • EC number

Gene names

    • ORF names
      CAC42_5191

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CQ-2017a
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Myriangiales > Elsinoaceae > Sphaceloma

Accessions

  • Primary accession
    A0A2K1QUC9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane108-127Helical
Transmembrane148-169Helical
Transmembrane230-252Helical
Transmembrane361-380Helical
Transmembrane400-426Helical
Transmembrane588-605Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Component of the NuA4 histone acetyltransferase complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region542-577Disordered
Region925-1021Disordered
Compositional bias931-953Basic and acidic residues
Compositional bias962-989Polar residues
Domain1065-1345MYST-type HAT

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,357
  • Mass (Da)
    151,900
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    8A9344C423DCD7937F06275041793DE8
MSINGSLVPSARDLIMVFPRLAQRAGAFAWYIPDQVDSLVSKMRQGGSVIAHATSANKSMATVTTSSASIFIQNTAVPEASVQANSTGLFSWVSSAVHFEGFRGFGGMFSYFGSRWALATFAVSIFLNRTHFYASSRQNLELRWRTRLLLYGLPIVLLLGEMLWVLQAMRCQTSPDYALFRYGDPDKNLAINFGGEGGFMHKLSSILLFWQDDAASCDAMSMSIKDGDKLSVLGSFSFVWPFFITICISQFVETLACALQGRQPAQDTGMTTFEHSLAFAECEAMISNALGLGVFNTSRDRPADASDSSGDQTLLTRSMILRRLNVPSEVLLISFISCVSHLSSAVLAVSGKRHKYRLVNTGIWALCYLSAFIWSFFRVMANPLGSDNDLGILRFPTVCIIGFIPHILIMIGISICAVIYSLALIVTMISLPPDAPANLTLRQRFSVAFDNLQANVQFSSSSSIKLNWSEDFYTNLLKVGFNILTAASEAVYLNEGSKIRIHDMTWLERKRLGELAESHREKLRVTIPNELTGGEIAPGLEYSDSNVTGGRSGYANERKSKSKKKGNTDGSGSDTALGMTQRRSRWELVVEFLNGVILLMTRIFARATAVSLAKLGVDYRPAWLMRHANLGTRNIKSRRHPGRASSLRDFWIIAEDGSLTLPKDSNVDVEQETRQRLLAMSSTASEDQVDDNLYQWWKGGGWWGDLDTSGDYAPLPTDDDLTSIISTSDASNMSSGWETDGQITPTEDDPFPSQSQAGNALNMSELSRLLDPKTAEEREEARILSRHLQNNGIMTRSQYRRRVNHDKAKILTLRRQGQSTSHVQIEAQVDEEQALEHFLLEQREKARVSSAQGRTWMSGADGMGAGGPQVGVKAMVEKEGEKRRAEILSIRTIRGNLSFYVHYEDFNKRLDEWVSHERIDLSQQVEWPLPEKPDAKTKKTAGKADKLDSSKTSKTSKAQKSNKRPRSATTTRDASATPTDASSKAGTRRPSLTGGKENRDPAVTILTPDVDGTPAPDDDGTVDLLDASESAAAAKAGPGENYSREEEIEKLRTGGSMTQNQTEISRVRNLERIQMGQHEIEPWYFSPYPSEFSDAEMVYICEMCLLYFDDGRQFRRHREKCTLLHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTSRDEHGHHLVGYFSKEKESAEGYNVACILTLPQFQRKGYGRLLIAFSYELSKREGKLGSPEKPLSDLGLLGYRAFWLETIVALLMELEEQGRKDISVEEVGTLTAMTTADVLHTLQTANMLRYSQKNHHVIVLTNAVVEQRERQIEKEKLKGKRSIDAEKLVWKPPVFTASSRTWNW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias931-953Basic and acidic residues
Compositional bias962-989Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NKHZ01000039
EMBL· GenBank· DDBJ
PNS18652.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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