A0A2K1K4G8 · A0A2K1K4G8_PHYPA

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site184ATP (UniProtKB | ChEBI)
Binding site247-248ATP (UniProtKB | ChEBI)
Binding site272-275ATP (UniProtKB | ChEBI)
Binding site273Mg2+ (UniProtKB | ChEBI); catalytic
Site274Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site301-303substrate
Active site303Proton acceptor
Binding site346-348substrate
Binding site402substrate
Binding site460-463substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      PHYPA_013135

Organism names

Accessions

  • Primary accession
    A0A2K1K4G8

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain177-484Phosphofructokinase
Region547-622Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    622
  • Mass (Da)
    67,884
  • Last updated
    2018-03-28 v1
  • Checksum
    BD7E87238D9E8B90
MACCSTRISPGLHTCAGGACVQRSGRAEACLGVSVAEEKGLSALRVSSEKIEERRKGFLKGEYHRKFVMHAVVMEVPVVRETRMGLNLNGTKVYTGAGGAILEDVPHLTDWLSGLPTYPNPLKYNPAYSAARQYFVEETDTVAKDVVVNINDVGHGIHFRRAGPRDQIYFKPEEVRACIVTCGGLCPGINTVIREIVCGLWTQYGVREILGIDGGYRGFYSKNTIDLTPKTVNDIHKRGGTVLQTSRGGHDLGKIVDSIQDRDINQVYIIGGDGTQKGANAIYEECKRRGLKVAVAGIPKTIDNDIDVIDKSFGFDTAVEEAQRAINAAHVEAESVQNGLGLVKLMGRYSGYIAMHATLASRDVDCCLIPEVPFYLHGSGGLIEFVRKRLRESGHMVIVVAEGAGQELMAESTVNNNDLKDASGNKLLLDVGLWLCTILKDHFQAEFRETLNLKYIDPKYMIRAIPSNASDNVYCTLLAHGAIHGAMAGYSGFTVGPINNRHCYIPIKRVVAKSRNVNVADRMWARLMSSTNQPNFSRYEEVVQRQRKLNAQKQEEVENEKSTLSSNGASKPGNERATEDESVLIHSGDRQEFPVSAGGLQPSPISSPVAGEPTPSVDHAAP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7I4EJZ1A0A7I4EJZ1_PHYPA460
A0A7I4EK51A0A7I4EK51_PHYPA444

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABEU02000009
EMBL· GenBank· DDBJ
PNR48658.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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