A0A2K1J0I5 · A0A2K1J0I5_PHYPA

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by fructose 2,6-bisphosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site176-177ATP (UniProtKB | ChEBI)
Site207Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site234-236substrate
Active site236Proton acceptor
Binding site273-274substrate; ligand shared between dimeric partners
Binding site281-283substrate
Binding site342substrate
Binding site448-451substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process
Biological Processphotosynthesis
Biological Processresponse to glucose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • ORF names
      PHYPA_022937

Organism names

Accessions

  • Primary accession
    A0A2K1J0I5

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain104-471Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    635
  • Mass (Da)
    69,347
  • Last updated
    2018-03-28 v1
  • Checksum
    4EBD12C0C3E68D69
MGIELHRKVSKLQGLSAVRAQYQPRVPPALKVTFAVRLARFWGIGEVDMCGSVKVSVGDASATAELSDRLAVSEAYPHTYGLPLVQLMSSGGPNATTAKHLPLRIGVAFCGRQSPGGHNVITGLFDALKSQNANSILIGFIGGTEGIFSQRTVELTNDMLKDFRNQGGYDLLGRTKDQIKSYQQIKDAKAACEALKLDVLVLIGGCGTNSDAAQLAEFFLESGCTTKVVGIPVTIDGDLKNQFVETNVGFDTTCKVYSQLISNICTDALSAEKYYYFIRLMGRQASHVSLECTLQSQSNMVLLGEEVANSKMTLFDVTMQICDAIQARGEQGKNYGVVLLPEGLIERIPEFRALLQEINTLRKQDEDIGVDNISSRLTLWAAALYDFLPIFIKKQLLLDRESDGSVQLSQIETEKLLAQLVDTEMIRRTKTGLYEGKKFNAICHFFGYQARGSLPSNFDCNYAYTLGQTAYYVAQAGLTGYMATVANLKQDVSEWRCGGAPLTAMMSVKRWLRGPGVSQTGKPAVHTTEVDLKGKPYGLLTQHASSWLMDDLYRNPGPIQYAGPGADLTTITLSIEDNDYIGEIQEFYAYLDKVKEIVKPGCAGEVLKAALSSMASVTDILTAMSAPSYRSLTPF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABEU02000018
EMBL· GenBank· DDBJ
PNR35038.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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