A0A2K1IYT1 · A0A2K1IYT1_PHYPA
- ProteinUbiquitin carboxyl-terminal hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids817 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Catalytic activity
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 180 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 183 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 200 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 213 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 317 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 777 | Proton acceptor | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | linear polyubiquitin binding | |
Molecular Function | Met1-linked polyubiquitin deubiquitinase activity | |
Molecular Function | zinc ion binding | |
Biological Process | auxin-activated signaling pathway | |
Biological Process | cellular response to gibberellin stimulus | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | leaf morphogenesis | |
Biological Process | protein deubiquitination | |
Biological Process | proteolysis | |
Biological Process | regulation of cell population proliferation | |
Biological Process | root hair elongation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Bryophyta > Bryophytina > Bryopsida > Funariidae > Funariales > Funariaceae > Physcomitrium
Accessions
- Primary accessionA0A2K1IYT1
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 156-266 | UBP-type | ||||
Sequence: QVSPYALSLQQVQNGVKVPPSGWKCSKCDKVDNLWMNLTDGTILCGRRNWDGTGGNNHALEHYQETNYPLAVKLGTITADLEGADVYSYAEDDTVEDPLLAEHLAHFGIDF | ||||||
Domain | 308-815 | USP | ||||
Sequence: TGLANLGNSCYLASVVQAVFSTKDFQRYYYENVKLDDAFKQAPADPTLDLHMQLSKLAHGILSGKYAVPSKKGQDNEVAEEPKGKNALTSMLQGQDGIPPRMFKSLIGTGHPEFASSRQQDALEFFQHFLDQVEQNHVAAVGEDPARCFKFCVEERIMCSVSKKVKYTKKTDNILSLNIPLRAAVNKDEVAAYEKNLAQKELAGEKLSDEEIVRPRVPLSACLENFSAPEEVMDFYSSAINARTTAIKTTRLATFPDYLVLHMRKFVLAAGWVPKKLDVFIDVPDEIDISDMRSKGPQPDEQFLPETPDGIPEQVDSAADEAIVSQLADMGFPRIRCEKAAIQTLNSGLEEAMNWLLVHMDDPDIDDPITRVGNNETSSVTALNESDVETLVSFGFLPEMARKALKATGGDMERAAEWILNHPEESMAMELDVGACTQDTQAEVKYPDGSGKYRLLAFVSHMGTSTQSGHYVCHVRKNDRWVIFNDCKVAVSGDPPKDMGYLYFFERV | ||||||
Domain | 625-666 | UBA | ||||
Sequence: AADEAIVSQLADMGFPRIRCEKAAIQTLNSGLEEAMNWLLVH | ||||||
Domain | 689-729 | UBA | ||||
Sequence: ALNESDVETLVSFGFLPEMARKALKATGGDMERAAEWILNH |
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length817
- Mass (Da)91,331
- Last updated2018-03-28 v1
- Checksum9C1B2E71149EF269
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7I4BKD3 | A0A7I4BKD3_PHYPA | 810 | |||
A0A7I4F9T2 | A0A7I4F9T2_PHYPA | 775 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ABEU02000019 EMBL· GenBank· DDBJ | PNR34421.1 EMBL· GenBank· DDBJ | Genomic DNA |