A0A2J9E265 · A0A2J9E265_9GAMM

Function

function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site255
Active site550Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Molecular Functionpeptide-methionine (S)-S-oxide reductase activity
Biological Processprotein modification process
Biological Processprotein repair
Biological Processresponse to oxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Peptide methionine sulfoxide reductase MsrA
  • EC number
  • Short names
    Protein-methionine-S-oxide reductase
  • Alternative names
    • Peptide-methionine (S)-S-oxide reductase
      (Peptide Met(O) reductase
      )
  • Recommended name
    Peptide methionine sulfoxide reductase MsrB
  • EC number
  • Alternative names
    • Peptide-methionine (R)-S-oxide reductase

Gene names

    • Name
      msrB
    • Synonyms
      msrA
    • ORF names
      A6J60_002050

Organism names

  • Taxonomic identifier
  • Strain
    • FDAARGOS_221
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Psychrobacter

Accessions

  • Primary accession
    A0A2J9E265

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501437553825-578Multifunctional fusion protein

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain46-201Thioredoxin
Region208-237Disordered
Compositional bias214-237Polar residues
Domain438-561MsrB

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    578
  • Mass (Da)
    63,387
  • Last updated
    2018-03-28 v1
  • Checksum
    82FD78EB300ADDF8
MHPQLKRMTLLTGFIIASSSLLPACGNVNSDNSAKQTMQSSNTGVTDSRDMLPSDVLNQLNGLPQLTKGLGESGTDVLDPNKPTLVKLWASWCPLCLGTLEETETWRKDAAFSGLNVVTVASPGHLNEKDEADFTQWYAGVQSDYPKLPVLIDNSGSLIKQLGVQVYPSWAILDKQGNLVRLIKGNLTEEQAYALAENASNDFADLKNSKAKPAQAGVDSSQSAKSDTPNNKNGVYYNSDGAPINTKTIYLAGGCFWGLEAYMERVDGVVDAISGYANGNPSLTDPSYEQVIAGSGHAETVKVVYDADKIDLETVLKYYLRVIDPTSLNKQGNDRGVQYRTGIYYTDASDKAVVEQALQSIESKYSKPIVVENKPLQNFSLAEEYHQDYLAKNPNGYCHIDLSLADDKLQSTSKTVKLAPANTVAEALNPKRYANFDKNALKNTLTKSQYEITQKAGTERAFSHEYDHLFAPGIYVDVVSGEPLFLSTHKYDSGCGWPSFWQPIAPDVITEHKDTAYNMVRTEVRSRVADSHLGHVFNDGPKDKTGLRYCINGGALQFIPVDKMPQSGYGVFVDQVKR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias214-237Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NWFK02000001
EMBL· GenBank· DDBJ
PNK61779.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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