A0A2J9E265 · A0A2J9E265_9GAMM
- ProteinMultifunctional fusion protein
- GenemsrB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids578 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + CHEBI:57844 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58772
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 255 | |||||
Sequence: C | ||||||
Active site | 550 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | protein modification process | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
- Recommended namePeptide methionine sulfoxide reductase MsrB
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Psychrobacter
Accessions
- Primary accessionA0A2J9E265
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MHPQLKRMTLLTGFIIASSSLLPA | ||||||
Chain | PRO_5014375538 | 25-578 | Multifunctional fusion protein | |||
Sequence: CGNVNSDNSAKQTMQSSNTGVTDSRDMLPSDVLNQLNGLPQLTKGLGESGTDVLDPNKPTLVKLWASWCPLCLGTLEETETWRKDAAFSGLNVVTVASPGHLNEKDEADFTQWYAGVQSDYPKLPVLIDNSGSLIKQLGVQVYPSWAILDKQGNLVRLIKGNLTEEQAYALAENASNDFADLKNSKAKPAQAGVDSSQSAKSDTPNNKNGVYYNSDGAPINTKTIYLAGGCFWGLEAYMERVDGVVDAISGYANGNPSLTDPSYEQVIAGSGHAETVKVVYDADKIDLETVLKYYLRVIDPTSLNKQGNDRGVQYRTGIYYTDASDKAVVEQALQSIESKYSKPIVVENKPLQNFSLAEEYHQDYLAKNPNGYCHIDLSLADDKLQSTSKTVKLAPANTVAEALNPKRYANFDKNALKNTLTKSQYEITQKAGTERAFSHEYDHLFAPGIYVDVVSGEPLFLSTHKYDSGCGWPSFWQPIAPDVITEHKDTAYNMVRTEVRSRVADSHLGHVFNDGPKDKTGLRYCINGGALQFIPVDKMPQSGYGVFVDQVKR |
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 46-201 | Thioredoxin | ||||
Sequence: TDSRDMLPSDVLNQLNGLPQLTKGLGESGTDVLDPNKPTLVKLWASWCPLCLGTLEETETWRKDAAFSGLNVVTVASPGHLNEKDEADFTQWYAGVQSDYPKLPVLIDNSGSLIKQLGVQVYPSWAILDKQGNLVRLIKGNLTEEQAYALAENASN | ||||||
Region | 208-237 | Disordered | ||||
Sequence: NSKAKPAQAGVDSSQSAKSDTPNNKNGVYY | ||||||
Compositional bias | 214-237 | Polar residues | ||||
Sequence: AQAGVDSSQSAKSDTPNNKNGVYY | ||||||
Domain | 438-561 | MsrB | ||||
Sequence: KNALKNTLTKSQYEITQKAGTERAFSHEYDHLFAPGIYVDVVSGEPLFLSTHKYDSGCGWPSFWQPIAPDVITEHKDTAYNMVRTEVRSRVADSHLGHVFNDGPKDKTGLRYCINGGALQFIPV |
Sequence similarities
Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length578
- Mass (Da)63,387
- Last updated2018-03-28 v1
- Checksum82FD78EB300ADDF8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 214-237 | Polar residues | ||||
Sequence: AQAGVDSSQSAKSDTPNNKNGVYY |