A0A2J8LPY6 · A0A2J8LPY6_PANTR

Function

function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentaxonemal microtubule
Cellular Componentcondensed chromosome
Cellular Componentcytoplasmic ribonucleoprotein granule
Cellular Componentcytosol
Cellular Componentneuromuscular junction
Cellular Componentplasma membrane
Cellular Componentrecycling endosome
Cellular Componentsperm flagellum
Molecular FunctionGTP binding
Molecular Functionhydrolase activity
Molecular Functionidentical protein binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein-containing complex binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processadult locomotory behavior
Biological Processcellular response to calcium ion
Biological Processcentrosome cycle
Biological Processcerebellar cortex morphogenesis
Biological Processcerebral cortex development
Biological Processdentate gyrus development
Biological Processflagellated sperm motility
Biological Processforebrain morphogenesis
Biological Processgene expression
Biological Processglial cell differentiation
Biological Processhomeostasis of number of cells within a tissue
Biological Processintracellular protein transport
Biological Processlocomotory exploration behavior
Biological Processmemory
Biological Processmicrotubule polymerization
Biological Processmotor behavior
Biological Processneuron apoptotic process
Biological Processneuron migration
Biological Processneuron projection arborization
Biological Processorganelle transport along microtubule
Biological Processpyramidal neuron differentiation
Biological Processregulation of synapse organization
Biological Processresponse to L-glutamate
Biological Processresponse to mechanical stimulus
Biological Processresponse to tumor necrosis factor
Biological Processsmoothened signaling pathway
Biological Processstartle response
Biological Processsynapse organization
Biological Processvisual learning

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin alpha chain

Gene names

    • ORF names
      CK820_G0026875

Organism names

  • Taxonomic identifier
  • Strain
    • Yerkes chimp pedigree #C0471
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2J8LPY6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Component of sperm flagellar doublet microtubules.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain49-246Tubulin/FtsZ GTPase
Domain248-393Tubulin/FtsZ 2-layer sandwich
Region432-451Disordered

Sequence similarities

Belongs to the tubulin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    50,136
  • Last updated
    2018-03-28 v1
  • Checksum
    00F8429A4A10E5FE
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBAG03000280
EMBL· GenBank· DDBJ
PNI49336.1
EMBL· GenBank· DDBJ
Genomic DNA
NBAG03000280
EMBL· GenBank· DDBJ
PNI49340.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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