A0A2J7QDH2 · A0A2J7QDH2_9NEOP
- ProteinProstaglandin reductase 1
- GenePTGR1_5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids421 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPHThis reaction proceeds in the forward direction.
- 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + H+ + NADPHThis reaction proceeds in the backward direction.
- 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + H+ + NADPHThis reaction proceeds in the backward direction.
- 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + H+ + NADPHThis reaction proceeds in the backward direction.
- 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + H+ + NADPHThis reaction proceeds in the forward direction.
- 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + H+ + NADPHThis reaction proceeds in the backward direction.
- 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPHThis reaction proceeds in the forward direction.
- NADP+ + nonan-2-one = (3E)-nonen-2-one + H+ + NADPHThis reaction proceeds in the backward direction.
- NADP+ + octanal = (2E)-octenal + H+ + NADPHThis reaction proceeds in the backward direction.
- NADP+ + pentan-2-one = (E)-pent-3-en-2-one + H+ + NADPHThis reaction proceeds in the backward direction.
- decanal + NADP+ = (2E)-decenal + H+ + NADPHThis reaction proceeds in the backward direction.
- dodecanal + NADP+ = (2E)-dodecenal + H+ + NADPHThis reaction proceeds in the backward direction.
- hexanal + NADP+ = (E)-hex-2-enal + H+ + NADPHThis reaction proceeds in the backward direction.
- leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + H+ + NADPHThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 13-prostaglandin reductase activity | |
Molecular Function | 15-oxoprostaglandin 13-oxidase activity | |
Molecular Function | 2-alkenal reductase [NAD(P)+] activity |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin reductase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Dictyoptera > Blattodea > Blattoidea > Termitoidae > Kalotermitidae > Cryptotermitinae > Cryptotermes
Accessions
- Primary accessionA0A2J7QDH2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 102-419 | Enoyl reductase (ER) | ||||
Sequence: KENDFQLVEEDLPALRDREILCEAVWLSVDPYMRPFSNNFPTGVTMTGTQVAKVTESCHPEYKVGMHVVGDFGWQTRAVVNADDPGASLWLEKPYIIPDFSGLPLSLALGVLGMPGNTAYFGFLEICDPKPGDVVVVSGAAGAVGSHVGQIAQLKGCKVIGFTGSDEKVKWLVDELRFDAAFNYKTTDVVEALKQSTPEGVDCYFDNVGGALSSAVISQMRFRGRISVCGSISSYNADISKLPQAPDIQRTVLRKELKMEGFSVKYWNDRWDEGIKQNLQWIKEGKLVYRETVTEGFENMTKAFIGMLRGENIGKAVV |
Sequence similarities
Belongs to the NADP-dependent oxidoreductase L4BD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length421
- Mass (Da)47,377
- Last updated2018-03-28 v1
- ChecksumF79E4476EE52DD3F
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2J7QDF6 | A0A2J7QDF6_9NEOP | PTGR1_5 | 275 | ||
A0A2J7QDF8 | A0A2J7QDF8_9NEOP | PTGR1_5 | 402 | ||
A0A2J7QDG3 | A0A2J7QDG3_9NEOP | PTGR1_5 | 337 | ||
A0A2J7QDG7 | A0A2J7QDG7_9NEOP | PTGR1_5 | 288 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NEVH01015823 EMBL· GenBank· DDBJ | PNF26623.1 EMBL· GenBank· DDBJ | Genomic DNA |