A0A2J6MMB3 · A0A2J6MMB3_9BURK

  • Protein
    Orotate phosphoribosyltransferase
  • Gene
    pyrE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site1045-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site1055-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site1085-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site134orotate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionorotate phosphoribosyltransferase activity
Biological Process'de novo' UMP biosynthetic process
Biological Processpyrimidine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotate phosphoribosyltransferase
  • EC number
  • Short names
    OPRT
    ; OPRTase

Gene names

    • Name
      pyrE
    • ORF names
      CY652_19940

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WAC0059
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia

Accessions

  • Primary accession
    A0A2J6MMB3

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain66-160Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    228
  • Mass (Da)
    25,452
  • Last updated
    2018-03-28 v1
  • Checksum
    DA913B1CD73531A7
MTGFDRQTISETTARMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISYPRLRRGLMEMAEATILRDVGYEQIDAVAGGETAGIPFAAWLSDRLMVPMQYVRKKPKGFGRNAQIEGLLTEGQRVLLVEDLTTDSRSKINFINALRTAGAEVNHCFVLFHYNIFKESVSVLKDIGVELHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATAAPQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PNEO01000021
EMBL· GenBank· DDBJ
PLZ00730.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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