A0A2J5I9J8 · A0A2J5I9J8_9EURO

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site72-77FMN (UniProtKB | ChEBI)
Binding site123-126FMN (UniProtKB | ChEBI)
Binding site169-178FMN (UniProtKB | ChEBI)
Binding site204FMN (UniProtKB | ChEBI)
Binding site296NADP+ (UniProtKB | ChEBI)
Binding site451-454FAD (UniProtKB | ChEBI)
Binding site469-471FAD (UniProtKB | ChEBI)
Binding site486-489FAD (UniProtKB | ChEBI)
Binding site552NADP+ (UniProtKB | ChEBI)
Binding site614-615NADP+ (UniProtKB | ChEBI)
Binding site620-624NADP+ (UniProtKB | ChEBI)
Binding site656NADP+ (UniProtKB | ChEBI)
Binding site694FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      cprA
    • ORF names
      BDW42DRAFT_182392

Organism names

  • Taxonomic identifier
  • Strain
    • IBT 19404
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    A0A2J5I9J8

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Cell membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-23Helical

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain66-221Flavodoxin-like
Domain277-538FAD-binding FR-type
Region676-695Disordered

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    695
  • Mass (Da)
    76,629
  • Last updated
    2018-03-28 v1
  • Checksum
    8365EA9E584106CE
MAQLDTLDMVVLVVLLVGSVAYFSKGVYWGIPKDPYATSGAAMNGAAAGGKSRDIIEKMDETGKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADLEDYDYENLDKFPEDKVAFFVLATYGEGEPTDNAVEFYQFVTGEDVAFESGATAEEKPLSSLNFVTFGLGNNTYEHYNAMVRQVDTALRNLGANRIGTAGEGDDGAGTMEEDFLAWKEPMWTALSETMNLQEREAVYEPVFNVEEDESLSPEDDTVYLGEPTQSHLQGNANGPFSAHNPFIAPIVESSELFNVKDRNCLHMEISIAGSNLTYQTGDHIAIWPTNAGAEVDRFLQVFGLEGKRHTVVNIKGLDVTAKVPIPTPTTYDAAVRYYLEVCAPVSRQFVSTLAAFAPDDESKAEIVRLGSDKDYFHEKITNRCFNIAQALQTITPKPFTAVPFSLLIEGLTKLQPRYYSISSSSLVQKDKISITAVVESVRLPGESHIVKGVTTNYLFALKQKQNGDPSPDAHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPSKPIIMVGPGTGVAPFRGFIQERAALAAKGEKVGTTLLFFGCRKSDEDFLYQDEFKAYQEQLGDSLKIITAFSRETSQKVYVQHRLREHSELVSDLLKQKATFYVCGDAANMAREVNLVLGQIIAKQRGLPAEKGEEMVKHMRSSGSYQEDVWS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ559497
EMBL· GenBank· DDBJ
PLN86714.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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