A0A2J5HZJ1 · A0A2J5HZJ1_9EURO
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids520 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + NAD+ + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H+
- 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + 2 H+
- pentanal + NAD+ + H2O = pentanoate + NADH + 2 H+
- propanal + NAD+ + H2O = propanoate + NADH + 2 H+
- spermine monoaldehyde + NAD+ + H2O = N-(2-carboxyethyl)spermidine + NADH + 2 H+
- hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
- imidazole-4-acetaldehyde + NAD+ + H2O = imidazole-4-acetate + NADH + 2 H+
- acrolein + NAD+ + H2O = acrylate + NADH + 2 H+
- butanal + NAD+ + H2O = butanoate + NADH + 2 H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 275 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aldehyde dehydrogenase (NAD+) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A2J5HZJ1
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length520
- Mass (Da)55,689
- Last updated2018-03-28 v1
- Checksum75B311BDC6F8D385
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KZ559523 EMBL· GenBank· DDBJ | PLN82914.1 EMBL· GenBank· DDBJ | Genomic DNA |