A0A2I6SDL0 · A0A2I6SDL0_MISAN
- ProteinElongation of very long chain fatty acids protein 4
- Geneelovl4b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids300 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity
- a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
Pathway
Lipid metabolism; fatty acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | fatty acid elongase activity | |
Biological Process | fatty acid elongation, polyunsaturated fatty acid | |
Biological Process | fatty acid elongation, saturated fatty acid | |
Biological Process | long-chain fatty-acyl-CoA biosynthetic process | |
Biological Process | unsaturated fatty acid biosynthetic process | |
Biological Process | very long-chain fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameElongation of very long chain fatty acids protein 4
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cobitidae > Cobitinae > Misgurnus
Accessions
- Primary accessionA0A2I6SDL0
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 36-56 | Helical | ||||
Sequence: LPTLGISVLYLLFLWAGPLYM | ||||||
Transmembrane | 68-88 | Helical | ||||
Sequence: LIVYNFSMVLLNFYICKELIL | ||||||
Transmembrane | 118-136 | Helical | ||||
Sequence: WWYYISKGVEFLDTVFFIM | ||||||
Transmembrane | 148-165 | Helical | ||||
Sequence: VYHHCTMFILWWIGIKWV | ||||||
Transmembrane | 171-194 | Helical | ||||
Sequence: FFGATINSGIHVLMYGYYGLAAFG | ||||||
Transmembrane | 206-223 | Helical | ||||
Sequence: YLTIIQMIQFHVTISHAA | ||||||
Transmembrane | 235-256 | Helical | ||||
Sequence: WMQWALIGYAVTFIILFANFYY |
Keywords
- Cellular component
Interaction
Subunit
Oligomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 271-300 | Disordered | ||||
Sequence: AANGISNGISKTPEFVENGKKPKKERAKSD | ||||||
Compositional bias | 286-300 | Basic and acidic residues | ||||
Sequence: VENGKKPKKERAKSD |
Sequence similarities
Belongs to the ELO family. ELOVL4 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)34,996
- Last updated2018-03-28 v1
- ChecksumE8D79DF272298406
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 286-300 | Basic and acidic residues | ||||
Sequence: VENGKKPKKERAKSD |