A0A2I6QLJ4 · A0A2I6QLJ4_9BACT

  • Protein
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • Gene
    panB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8Mg2+ (UniProtKB | ChEBI)
Binding site8-93-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site473-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site773-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site79Mg2+ (UniProtKB | ChEBI)
Active site147Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB

Organism names

Accessions

  • Primary accession
    A0A2I6QLJ4

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Family & Domains

Sequence similarities

Belongs to the PanB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    235
  • Mass (Da)
    25,402
  • Last updated
    2018-03-28 v1
  • Checksum
    26173C1A4FEB3A21
MDAILVGDSMGNTIMGRRDTLSVTVDDILHHTKMVTRAVERCFVIADMPFLSYQVNHEDALRNAGRLVAEGGAHAVKLEGGPDKYGDAITTILKAGVPVMGHIGLTPQSVHQFGGYKVQGRDEASRARLLREAKGLQDLGCFAVVLECMPPDLAEEITKSLFIPTIGIGAGPGCDGQVLVMHDMLGWGTTRFTKTFADVKGIMKQAFEDYVTEVRSGAFPQAEHTYAPKVERVAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF620023
EMBL· GenBank· DDBJ
AUN37084.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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