A0A2I6J4G4 · A0A2I6J4G4_9ARAC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Araneae > Araneomorphae > Haplogynae > Leptonetoidea > Leptonetidae > Leptonetela

Accessions

  • Primary accession
    A0A2I6J4G4

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-54Helical
Transmembrane75-97Helical
Transmembrane117-142Helical
Transmembrane154-181Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-205Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    205
  • Mass (Da)
    22,146
  • Last updated
    2018-03-28 v1
  • Checksum
    38C8C9462A0FA19D
GTAMSVLIRVELGQGGSFLGNDHLYNVIVTAHAFIMIFFMVMPILIGGFGNWLVPLMVGAPDMAFPRMNNLSFWLLPPSLFLLLISGLVEMGVGTGWTVYPPLAAYLGHSFVSVDYAIFSLHLAGASSIMGAVNFITTILNMRMNGLSMDKMSLFVWSVLITAVLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPVLFQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue205

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MG573685
EMBL· GenBank· DDBJ
AUL81625.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573686
EMBL· GenBank· DDBJ
AUL81626.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573687
EMBL· GenBank· DDBJ
AUL81627.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573688
EMBL· GenBank· DDBJ
AUL81628.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573690
EMBL· GenBank· DDBJ
AUL81630.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573697
EMBL· GenBank· DDBJ
AUL81637.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573698
EMBL· GenBank· DDBJ
AUL81638.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573699
EMBL· GenBank· DDBJ
AUL81639.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573700
EMBL· GenBank· DDBJ
AUL81640.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573701
EMBL· GenBank· DDBJ
AUL81641.1
EMBL· GenBank· DDBJ
Genomic DNA
MG573702
EMBL· GenBank· DDBJ
AUL81642.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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