A0A2I5SJS2 · A0A2I5SJS2_ECOLX

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37-385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site695-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site69GMP (UniProtKB | ChEBI)
Binding site88-965-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site89Mg2+ (UniProtKB | ChEBI)
Binding site92guanine (UniProtKB | ChEBI)
Binding site92xanthine (UniProtKB | ChEBI)
Binding site92-96GMP (UniProtKB | ChEBI)
Binding site134-135GMP (UniProtKB | ChEBI)
Binding site135guanine (UniProtKB | ChEBI)
Binding site135xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      D3C88_01835
      , NCTC9001_00688

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • S308
    • NCTC9001
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A2I5SJS2

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-143Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    152
  • Mass (Da)
    16,984
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    84B4AA49C6CC2EC10CA1215ADD15A8E0
MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFITIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMGVVFVPPISGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QXHA01000100
EMBL· GenBank· DDBJ
RIB43607.1
EMBL· GenBank· DDBJ
Genomic DNA
CAADIS010000002
EMBL· GenBank· DDBJ
VFS04168.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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