A0A2I5S491 · A0A2I5S491_ORCGA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • Gruta das Agulhas
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Peracarida > Amphipoda > Senticaudata > Talitrida > Talitroidea > Talitridae > Orchestia

Accessions

  • Primary accession
    A0A2I5S491

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-53Helical
Transmembrane65-90Helical
Transmembrane102-120Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-121Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    121
  • Mass (Da)
    13,210
  • Last updated
    2018-03-28 v1
  • MD5 Checksum
    290952DEA8168D3F76E46FA5900EB525
SATMIIAVPTGIKVFSWLGTLQGGSLNFSPSMLWALGFIFLFTVGGLTGVMLANSSIDIVLHDTYYVVAHFHYVLSMGAVFGIFAGFVHWFSVFTGLTLSPAMAKIHFYIMFIGVNITFFP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue121

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY379005
EMBL· GenBank· DDBJ
AUG84523.1
EMBL· GenBank· DDBJ
Genomic DNA
KY379006
EMBL· GenBank· DDBJ
AUG84524.1
EMBL· GenBank· DDBJ
Genomic DNA
KY379026
EMBL· GenBank· DDBJ
AUG84544.1
EMBL· GenBank· DDBJ
Genomic DNA
MH042533
EMBL· GenBank· DDBJ
AXU41439.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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