A0A2I3GQX0 · A0A2I3GQX0_NOMLE

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

1812100200300400500600700800
Type
IDPosition(s)Description
Binding site51Ca2+ (UniProtKB | ChEBI)
Binding site52Ca2+ (UniProtKB | ChEBI)
Active site87Nucleophile
Binding site87Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Binding site259Ca2+ (UniProtKB | ChEBI)
Binding site260Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular space
Cellular ComponentGolgi stack
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Molecular Functionarylsulfatase activity
Molecular Functioncalcium ion binding
Molecular Functionglycosaminoglycan binding
Molecular FunctionN-acetylglucosamine-6-sulfatase activity
Biological Processbone development
Biological Processchondrocyte development
Biological Processembryonic skeletal system development
Biological Processesophagus smooth muscle contraction
Biological Processglial cell-derived neurotrophic factor receptor signaling pathway
Biological Processglomerular basement membrane development
Biological Processglomerular filtration
Biological Processheparan sulfate proteoglycan metabolic process
Biological Processinnervation
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of endothelial cell proliferation
Biological Processnegative regulation of fibroblast growth factor receptor signaling pathway
Biological Processnegative regulation of prostatic bud formation
Biological Processpositive regulation of BMP signaling pathway
Biological Processpositive regulation of vascular endothelial growth factor production
Biological Processpositive regulation of Wnt signaling pathway
Biological Processvascular endothelial growth factor receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Arylsulfatase
  • EC number
  • Alternative names
    • N-acetylglucosamine-6-sulfatase

Gene names

    • Name
      SULF1

Organism names

Accessions

  • Primary accession
    A0A2I3GQX0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_501416167323-812Arylsulfatase
Modified residue873-oxoalanine (Cys)

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, coiled coil.

Type
IDPosition(s)Description
Domain43-316Sulfatase N-terminal
Region451-477Disordered
Domain477-621Extracellular sulfatase C-terminal
Region514-550Disordered
Coiled coil585-612
Domain624-682Extracellular sulfatase C-terminal

Sequence similarities

Belongs to the sulfatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    812
  • Mass (Da)
    94,024
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    E17AAFC5A94ED59EF74ED8E741CA77E0
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQATHEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKTPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLMETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPSDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQTRSLSVEFEGEIYDINLEEEELQVLQPRNTAKRHDEGHKGPRALQASSGGNRGGMLADSSNTVGPPTTVRVTHKCFILPNDTIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNLREVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENRRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQCNPRPKNLDVGNKDGGSYGLHRGQLWDGWEG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G1RKE7G1RKE7_NOMLESULF1646
G1RKF0G1RKF0_NOMLESULF1638

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADFV01083784
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ADFV01083785
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ADFV01083786
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ADFV01083787
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ADFV01083788
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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