A0A2I3GQX0 · A0A2I3GQX0_NOMLE
- ProteinArylsulfatase
- GeneSULF1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids812 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- an aryl sulfate + H2O = a phenol + sulfate + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 51 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 52 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 87 | Nucleophile | |||
Binding site | 87 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 259 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 260 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArylsulfatase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hylobatidae > Nomascus
Accessions
- Primary accessionA0A2I3GQX0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5014161673 | 23-812 | Arylsulfatase | ||
Modified residue | 87 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-316 | Sulfatase N-terminal | |||
Region | 451-477 | Disordered | |||
Domain | 477-621 | Extracellular sulfatase C-terminal | |||
Region | 514-550 | Disordered | |||
Coiled coil | 585-612 | ||||
Domain | 624-682 | Extracellular sulfatase C-terminal | |||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length812
- Mass (Da)94,024
- Last updated2018-02-28 v1
- MD5 ChecksumE17AAFC5A94ED59EF74ED8E741CA77E0
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ADFV01083784 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ADFV01083785 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ADFV01083786 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ADFV01083787 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ADFV01083788 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |