p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.Kanazawa S., Ilic D., Hashiyama M., Noumura T., Yamamoto T., Suda T., Aizawa S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCBlood 87:865-870 (1996)Mapped to12
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice.Ilic D., Furuta Y., Kanazawa S., Takeda N., Sobue K., Nakatsuji N., Nomura S., Fujimoto J., Okada M., Yamamoto T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCNature 377:539-544 (1995)Mapped to22
Blood-brain barrier-restricted translocation of <i>Toxoplasma gondii</i> from cortical capillaries.Olivera G.C., Ross E.C., Peuckert C., Barragan A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCElife 10:e69182-e69182 (2021)Mapped to8
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Paul R., Luo M., Mo X., Lu J., Yeo S.K., Guan J.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCBreast Cancer Res 22:59-59 (2020)Mapped to9
Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair.Thomas K.S., Owen K.A., Conger K., Llewellyn R.A., Bouton A.H., Casanova J.E.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCSci Rep 9:4497-4497 (2019)Mapped to17
Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF.Jia C., Keasey M.P., Lovins C., Hagg T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCGlia 66:2456-2469 (2018)Mapped to10
MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development.Liu W., Han F., Qu S., Yao Y., Zhao J., Akhtar M.L., Ci Y., Zhang H., Li H.[...], Li Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCCell Death Dis 9:999-999 (2018)Mapped to91
FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis.Heim J.B., McDonald C.A., Wyles S.P., Sominidi-Damodaran S., Squirewell E.J., Li M., Motsonelidze C., Bottcher R.T., van Deursen J., Meves A.View abstractCategoriesFunction, PTM / Processing, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCPLoS One 13:e0200558-e0200558 (2018)Mapped to8
Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.He Y., Sun X., Wang L., Mishina Y., Guan J.L., Liu F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCGenesis 55:0-0 (2017)Mapped to22
Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice.Alexopoulou A.N., Lees D.M., Bodrug N., Lechertier T., Fernandez I., D'Amico G., Dukinfield M., Batista S., Tavora B.[...], Hodivala-Dilke K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCJ Pathol 242:358-370 (2017)Mapped to8
Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation.Li W., Chen L., Chen Z., Wu L., Feng J., Wang F., Shoff L., Li X., Donly K.J.[...], Chen S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCSci Rep 7:300-300 (2017)Mapped to17
Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart.Klawitter J., Seres T., Pennington A., Beatty J.T., Klawitter J., Christians U.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCJ Cell Biochem 118:2933-2940 (2017)Mapped to17
FAK signalling controls insulin sensitivity through regulation of adipocyte survival.Luk C.T., Shi S.Y., Cai E.P., Sivasubramaniyam T., Krishnamurthy M., Brunt J.J., Schroer S.A., Winer D.A., Woo M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCNat Commun 8:14360-14360 (2017)Mapped to35
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.Pryce B.R., Al-Zahrani K.N., Dufresne S., Belkina N., Labreche C., Patino-Lopez G., Frenette J., Shaw S., Sabourin L.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCSkelet Muscle 7:3-3 (2017)Mapped to91
Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.Misra A., Sheikh A.Q., Kumar A., Luo J., Zhang J., Hinton R.B., Smoot L., Kaplan P., Urban Z.[...], Greif D.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCJ Exp Med 213:451-463 (2016)Mapped to61
FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN- null T-ALL cells.You D., Xin J., Volk A., Wei W., Schmidt R., Scurti G., Nand S., Breuer E.K., Kuo P.C.[...], Zhang J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCCell Rep 10:2055-2068 (2015)Mapped to41
Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness.Hu H., Matter M.L., Issa-Jahns L., Jijiwa M., Kraemer N., Musante L., de la Vega M., Ninnemann O., Schindler D.[...], Kaindl A.M.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCAnn. Clin. Transl. Neurol. 1:1024-1035 (2014)Cited in1Mapped to61
Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.Batista S., Maniati E., Reynolds L.E., Tavora B., Lees D.M., Fernandez I., Elia G., Casanovas O., Lo Celso C.[...], Hodivala-Dilke K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCNat Commun 5:5054-5054 (2014)Mapped to12
Generation of point-mutant FAK knockin mice.Tavora B., Batista S., Alexopoulou A.N., Kostourou V., Fernandez I., Robinson S.D., Lees D.M., Serrels B., Hodivala-Dilke K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCGenesis 52:907-915 (2014)Mapped to8
GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.Morgan-Smith M., Wu Y., Zhu X., Pringle J., Snider W.D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCElife 3:e02663-e02663 (2014)Mapped to99+
Essential role for the SLK protein kinase in embryogenesis and placental tissue development.Al-Zahrani K.N., Sekhon P., Tessier D.R., Yockell-Lelievre J., Pryce B.R., Baron K.D., Howe G.A., Sriram R.K., Daniel K.[...], Sabourin L.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCDev Dyn 243:640-651 (2014)Mapped to39
Conditional knockout of myocyte focal adhesion kinase abrogates ischemic preconditioning in adult murine hearts.Perricone A.J., Bivona B.J., Jackson F.R., Vander Heide R.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCJ Am Heart Assoc 2:e000457-e000457 (2013)Mapped to10
p600 Plays Essential Roles in Fetal Development.Nakaya T., Ishiguro K., Belzil C., Rietsch A.M., Yu Q., Mizuno S., Bronson R.T., Geng Y., Nguyen M.D.[...], Nakatani Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCPLoS One 8:e66269-e66269 (2013)Mapped to24
FAK-heterozygous mice display enhanced tumour angiogenesis.Kostourou V., Lechertier T., Reynolds L.E., Lees D.M., Baker M., Jones D.T., Tavora B., Ramjaun A.R., Birdsey G.M.[...], Hodivala-Dilke K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCNat Commun 4:2020-2020 (2013)Mapped to8
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas.Konstantinidou G., Ramadori G., Torti F., Kangasniemi K., Ramirez R.E., Cai Y., Behrens C., Dellinger M.T., Brekken R.A.[...], Scaglioni P.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 95481PubMedEurope PMCCancer Discov 3:444-457 (2013)Mapped to16