Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A2I2YNX1 · A0A2I2YNX1_GORGO

Function

function

Endothelins are endothelium-derived vasoconstrictor peptides.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionendothelin B receptor binding
Molecular Functionhormone activity
Biological Processaxon extension
Biological Processaxon guidance
Biological Processcell population proliferation
Biological Processcell surface receptor signaling pathway
Biological Processestablishment of localization in cell
Biological Processintracellular calcium ion homeostasis
Biological Processintracellular magnesium ion homeostasis
Biological Processmelanocyte differentiation
Biological Processneural crest cell migration
Biological Processneutrophil chemotaxis
Biological Processpeptide hormone secretion
Biological Processpositive regulation of cell differentiation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of heart rate
Biological Processpositive regulation of hormone secretion
Biological Processpositive regulation of leukocyte chemotaxis
Biological Processpositive regulation of MAP kinase activity
Biological Processpositive regulation of mitotic nuclear division
Biological Processpositive regulation of potassium ion transmembrane transport
Biological Processpotassium ion transmembrane transport
Biological Processregulation of developmental pigmentation
Biological Processregulation of gene expression
Biological Processregulation of systemic arterial blood pressure by endothelin
Biological Processregulation of vasoconstriction
Biological Processvein smooth muscle contraction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endothelin-3
  • Alternative names
    • Preproendothelin-3

Gene names

    • Name
      EDN3

Organism names

Accessions

  • Primary accession
    A0A2I2YNX1

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_501418109417-224Endothelin-3

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region24-89Disordered
Domain96-117Endothelin-like toxin
Domain158-179Endothelin-like toxin

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    23,822
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    7B9BF26B67EA5F4A3DFFC9EF59A8FAEE
MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRSAGLLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSRQVGVKDRQSKQALGLHPPKLMPGSGLALAPSTCPRCLFQEGAP

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G3RAU4G3RAU4_GORGOEDN3219

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABD030117559
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help