A0A2I2Y2H0 · A0A2I2Y2H0_GORGO
- ProteinE3 ubiquitin-protein ligase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids911 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 878 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | protein ubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Gorilla
Accessions
- Primary accessionA0A2I2Y2H0
Proteomes
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-126 | C2 | ||||
Sequence: GLGEPVYGLSEDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPY | ||||||
Region | 178-202 | Disordered | ||||
Sequence: DSNDSASQHQEELPPPPLPPGWEEK | ||||||
Domain | 193-226 | WW | ||||
Sequence: PPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL | ||||||
Compositional bias | 244-261 | Basic and acidic residues | ||||
Sequence: AAHRRFRSRRHISEDLEP | ||||||
Region | 244-272 | Disordered | ||||
Sequence: AAHRRFRSRRHISEDLEPEPSEGGDVPEP | ||||||
Region | 285-312 | Disordered | ||||
Sequence: DSLGLALPPPPASPGSRTSPQELSEELS | ||||||
Region | 353-433 | Disordered | ||||
Sequence: LPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQS | ||||||
Compositional bias | 361-391 | Polar residues | ||||
Sequence: ASGSATNSNNHLIEPQIRRPRSLSSPTVTLS | ||||||
Domain | 433-466 | WW | ||||
Sequence: SFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL | ||||||
Domain | 484-517 | WW | ||||
Sequence: GPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL | ||||||
Domain | 576-910 | HECT | ||||
Sequence: RPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGV |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length911
- Mass (Da)104,922
- Last updated2018-02-28 v1
- ChecksumCE04AAED677AA506
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I2YEM7 | A0A2I2YEM7_GORGO | 975 | |||
A0A2I2ZWT1 | A0A2I2ZWT1_GORGO | 871 | |||
G3S3H5 | G3S3H5_GORGO | 967 | |||
A0A2I2YEE2 | A0A2I2YEE2_GORGO | 921 | |||
A0A2I2YEY2 | A0A2I2YEY2_GORGO | 869 | |||
A0A2I2YAY5 | A0A2I2YAY5_GORGO | 106 | |||
A0A2I2YD63 | A0A2I2YD63_GORGO | 1178 | |||
A0A2I2YHK1 | A0A2I2YHK1_GORGO | 927 | |||
G3RD09 | G3RD09_GORGO | 955 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 244-261 | Basic and acidic residues | ||||
Sequence: AAHRRFRSRRHISEDLEP | ||||||
Compositional bias | 361-391 | Polar residues | ||||
Sequence: ASGSATNSNNHLIEPQIRRPRSLSSPTVTLS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CABD030109709 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109710 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109711 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109712 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109713 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109714 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109715 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109716 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109717 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABD030109718 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |