A0A2I2V1M2 · A0A2I2V1M2_FELCA

Function

function

Polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 or 2 Zn2+ ions per subunit.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentmitochondrial membrane
Cellular Componentmotile cilium
Molecular FunctionD-sorbitol dehydrogenase (acceptor) activity
Molecular FunctionD-xylulose reductase activity
Molecular Functionidentical protein binding
Molecular FunctionL-iditol 2-dehydrogenase (NAD+) activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessD-glucuronate catabolic process to D-xylulose 5-phosphate
Biological Processflagellated sperm motility
Biological Processfructose biosynthetic process
Biological Processsorbitol catabolic process
Biological Processxylitol catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sorbitol dehydrogenase
  • EC number
  • Short names
    SDH
    ; XDH
  • Alternative names
    • L-iditol 2-dehydrogenase
    • Polyol dehydrogenase
    • Xylitol dehydrogenase

Gene names

    • Name
      SORD

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A2I2V1M2

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion membrane
; Peripheral membrane protein
Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-347Enoyl reductase (ER)

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    38,343
  • Last updated
    2018-02-28 v1
  • Checksum
    7C3E05AC07B6FF77
MAAAKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWQHGRIGDFIVKKPMVLGHEASGTVVKVGSLVKHLKPGDRVAIEPGALREMDEFCKIGRYNLSPSIFFCATPPDDGNLCRFYKHNADFCYKLPDNVTFEEGALIEPLSVGIHACRRAGITLGNKVFVCGAGPIGLVTLIVAKAMGAAQVVVTDLSATRLSKAKEVGADFVLQISKESPKEIASKVEDLLGCKPEVTIECSGVELSIQAGIYATRSGGTLVLVGLGSEMTTVPLVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSRKGLGLKVMLKCDPNDQNP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04001761
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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