A0A2I2UXM8 · A0A2I2UXM8_FELCA

Function

function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by RHOA binding. Inhibited by Y-27632.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site105ATP (UniProtKB | ChEBI)
Active site198Proton acceptor

GO annotations

AspectTerm
Cellular Componentamyloid-beta complex
Cellular Componentbleb
Cellular Componentcentriole
Cellular Componentcytoplasm
Cellular Componentcytoplasmic stress granule
Cellular Componentcytoskeleton
Cellular ComponentGolgi membrane
Cellular Componentlamellipodium
Cellular Componentplasma membrane
Cellular Componentruffle
Cellular ComponentSchaffer collateral - CA1 synapse
Molecular Functionaspartic-type endopeptidase inhibitor activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionsmall GTPase binding
Biological Processactomyosin structure organization
Biological Processapical constriction
Biological Processbleb assembly
Biological Processblood vessel diameter maintenance
Biological Processcanonical NF-kappaB signal transduction
Biological Processcortical actin cytoskeleton organization
Biological Processembryonic morphogenesis
Biological Processepithelial to mesenchymal transition
Biological Processleukocyte tethering or rolling
Biological Processmembrane to membrane docking
Biological Processmitotic cytokinesis
Biological Processmotor neuron apoptotic process
Biological ProcessmRNA destabilization
Biological Processmyoblast migration
Biological Processnegative regulation of amyloid-beta formation
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of bicellular tight junction assembly
Biological Processnegative regulation of motor neuron apoptotic process
Biological Processnegative regulation of phosphorylation
Biological Processneuron projection arborization
Biological Processpodocyte cell migration
Biological Processpositive regulation of amyloid-beta clearance
Biological Processpositive regulation of autophagy
Biological Processpositive regulation of cardiac muscle hypertrophy
Biological Processpositive regulation of connective tissue replacement
Biological Processpositive regulation of dephosphorylation
Biological Processpositive regulation of focal adhesion assembly
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of MAPK cascade
Biological Processprotein localization to plasma membrane
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of angiotensin-activated signaling pathway
Biological Processregulation of cell junction assembly
Biological Processregulation of cell migration
Biological Processregulation of establishment of endothelial barrier
Biological Processregulation of keratinocyte differentiation
Biological Processregulation of microtubule cytoskeleton organization
Biological Processregulation of neuron differentiation
Biological Processregulation of synapse maturation
Biological Processregulation of synaptic vesicle endocytosis
Biological Processresponse to angiotensin
Biological Processresponse to transforming growth factor beta
Biological ProcessRho protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-associated protein kinase
  • EC number

Gene names

    • Name
      ROCK1

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A2I2UXM8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, coiled coil, region.

TypeIDPosition(s)Description
Domain76-338Protein kinase
Domain341-409AGC-kinase C-terminal
Coiled coil432-898
Domain479-556REM-1
Coiled coil938-979
Domain949-1015RhoBD
Coiled coil1020-1100
Domain1118-1317PH
Domain1228-1283Phorbol-ester/DAG-type
Region1326-1355Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,355
  • Mass (Da)
    158,630
  • Last updated
    2019-12-11 v3
  • Checksum
    3AA1C4FB71C97420
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRSSPNVDKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKTQMDKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLSLQLEQESNKRVLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLTTQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSMLTKDLELLRKENEELTDKMRRTEEEYKLKKEEEINNLKATYEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSAKTSS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M3X9E5M3X9E5_FELCAROCK11137

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04003548
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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