A0A2I2UXM8 · A0A2I2UXM8_FELCA
- ProteinRho-associated protein kinase
- GeneROCK1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1355 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A2I2UXM8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 76-338 | Protein kinase | ||||
Sequence: YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFF | ||||||
Domain | 341-409 | AGC-kinase C-terminal | ||||
Sequence: DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSA | ||||||
Coiled coil | 432-898 | |||||
Sequence: IYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKTQMDKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLSLQLEQESNKRVLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLTTQLDLAETK | ||||||
Domain | 479-556 | REM-1 | ||||
Sequence: STVSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLTQLQKQLEEANDLLRT | ||||||
Coiled coil | 938-979 | |||||
Sequence: VSRLEETNSMLTKDLELLRKENEELTDKMRRTEEEYKLKKEE | ||||||
Domain | 949-1015 | RhoBD | ||||
Sequence: TKDLELLRKENEELTDKMRRTEEEYKLKKEEEINNLKATYEKNISTERTLKTQAVNKLAEIMNRKDF | ||||||
Coiled coil | 1020-1100 | |||||
Sequence: KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDS | ||||||
Domain | 1118-1317 | PH | ||||
Sequence: ESRIEGWLSIPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIP | ||||||
Domain | 1228-1283 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPC | ||||||
Region | 1326-1355 | Disordered | ||||
Sequence: RASPRTLSTRSTANQSFRKVVKNTSAKTSS |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,355
- Mass (Da)158,630
- Last updated2019-12-11 v3
- Checksum3AA1C4FB71C97420
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M3X9E5 | M3X9E5_FELCA | ROCK1 | 1137 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04003548 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |