A0A2I2UWG9 · A0A2I2UWG9_FELCA

Function

function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytosol
Cellular Componentextrinsic component of cytoplasmic side of plasma membrane
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP-dependent histone chaperone activity
Molecular Functionidentical protein binding
Molecular Functioninterleukin-1 receptor binding
Molecular Functionsignaling adaptor activity
Molecular FunctionTIR domain binding
Molecular FunctionToll-like receptor binding
Biological Process3'-UTR-mediated mRNA stabilization
Biological Processapoptotic process
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to oxidised low-density lipoprotein particle stimulus
Biological Processdefense response to Gram-positive bacterium
Biological Processdefense response to virus
Biological Processestablishment of endothelial intestinal barrier
Biological Processgene expression
Biological Processimmunoglobulin mediated immune response
Biological Processinduced systemic resistance
Biological Processinnate immune response
Biological Processinterleukin-1-mediated signaling pathway
Biological Processinterleukin-33-mediated signaling pathway
Biological ProcessJNK cascade
Biological Processleukocyte activation involved in inflammatory response
Biological Processlipopolysaccharide-mediated signaling pathway
Biological Processmicroglia differentiation
Biological ProcessMyD88-dependent toll-like receptor signaling pathway
Biological Processneutrophil activation involved in immune response
Biological Processneutrophil-mediated killing of bacterium
Biological Processphagocytosis
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of cytokine production involved in inflammatory response
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-17 production
Biological Processpositive regulation of interleukin-23 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of lymphocyte proliferation
Biological Processpositive regulation of macrophage cytokine production
Biological Processpositive regulation of NLRP3 inflammasome complex assembly
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of type I interferon production
Biological Processregulation of chemokine (C-X-C motif) ligand 1 production
Biological Processregulation of chemokine (C-X-C motif) ligand 2 production
Biological Processregulation of inflammatory response
Biological Processregulation of neutrophil migration
Biological Processresponse to molecule of fungal origin
Biological Processresponse to peptidoglycan
Biological Processskin development
Biological ProcessToll signaling pathway
Biological Processtoll-like receptor 4 signaling pathway
Biological Processtoll-like receptor 8 signaling pathway
Biological Processtype I interferon-mediated signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myeloid differentiation primary response protein MyD88

Gene names

    • Name
      MYD88

Organism names

  • Taxonomic identifier
  • Strain
    • Abyssinian
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    A0A2I2UWG9

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue256Phosphoserine

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-23Disordered
Domain44-121Death
Region139-158Disordered
Domain171-305TIR

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    34,430
  • Last updated
    2019-12-11 v3
  • Checksum
    BEDC32071D085B83
ARLDSAEAPGPAMAAGGSRAGSASPIPSASSLPLAALNVRVRRRLSLFLNVRTQVAADWTALAEEMGFEYLEIRQLEAHADPMGKLLDDWQGRPGASVGRLLELLTKLGRDDVLVELGPSIEEDCQKYILKQQQEESEKPLQVAAVDSSDPRTSELAGITTLDDPLGQMPERFDAFICYCPSDIQFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F5XTK8A0A5F5XTK8_FELCAMYD88158
A0A5F5XKH0A0A5F5XKH0_FELCAMYD88263
A0A5F5XP34A0A5F5XP34_FELCAMYD88203
A0A5F5XEQ8A0A5F5XEQ8_FELCAMYD88304

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANG04001816
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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