A0A2I2UQK0 · A0A2I2UQK0_FELCA
- Protein[histone H3]-lysine(36) N-trimethyltransferase
- GeneSETD2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2563 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-lysine(36) N-trimethyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis
Accessions
- Primary accessionA0A2I2UQK0
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Pro residues | ||||
Sequence: MKQLPPQPPPKMGDFY | ||||||
Region | 1-30 | Disordered | ||||
Sequence: MKQLPPQPPPKMGDFYDPEHPTPEEEENEA | ||||||
Region | 180-213 | Disordered | ||||
Sequence: STTVDSPPSSPPPPPPPPQATTPSPAPVTEPVAL | ||||||
Compositional bias | 185-213 | Pro residues | ||||
Sequence: SPPSSPPPPPPPPQATTPSPAPVTEPVAL | ||||||
Region | 235-548 | Disordered | ||||
Sequence: EPPVTTVPESSDVDTKQDAVSNSSEEHITQNLNEQADTPSQKEDSHIGKEEEIPDSSKSNLGSKKTGSKKKSSQSEGTFLASESDEDSVRTSSSQRSHDLKFSASIEKERDSKKSLAPLKSEDLGKSSRSKTERDDKYFSYSKLERDTRYISSRCRSERERRRSRSRSRSDRGSRTSLSYSRSERSHYYDSDRRYHRSSPYRERARYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSFSYRDLRTSSSYSKSDRDCKTESSYLEMEKRGKYSSKVERESKRTSENEAMKRCCSPPNELGFRRGSSYSKHDNSA | ||||||
Compositional bias | 238-272 | Polar residues | ||||
Sequence: VTTVPESSDVDTKQDAVSNSSEEHITQNLNEQADT | ||||||
Compositional bias | 273-292 | Basic and acidic residues | ||||
Sequence: PSQKEDSHIGKEEEIPDSSK | ||||||
Compositional bias | 293-322 | Polar residues | ||||
Sequence: SNLGSKKTGSKKKSSQSEGTFLASESDEDS | ||||||
Compositional bias | 335-406 | Basic and acidic residues | ||||
Sequence: KFSASIEKERDSKKSLAPLKSEDLGKSSRSKTERDDKYFSYSKLERDTRYISSRCRSERERRRSRSRSRSDR | ||||||
Compositional bias | 419-466 | Basic and acidic residues | ||||
Sequence: RSHYYDSDRRYHRSSPYRERARYSRPYTDNRARESSDSEEEYKKTYSR | ||||||
Compositional bias | 467-481 | Polar residues | ||||
Sequence: RTSSHSFSYRDLRTS | ||||||
Compositional bias | 482-522 | Basic and acidic residues | ||||
Sequence: SSYSKSDRDCKTESSYLEMEKRGKYSSKVERESKRTSENEA | ||||||
Region | 959-991 | Disordered | ||||
Sequence: QEEGSSIVLERRGRSEISLDEEGGRGHAHTSDD | ||||||
Compositional bias | 963-990 | Basic and acidic residues | ||||
Sequence: SSIVLERRGRSEISLDEEGGRGHAHTSD | ||||||
Region | 1031-1107 | Disordered | ||||
Sequence: HEDYSGSSESSSDESDSEDTDSDDSSFPRNRLQSVVVVPKNSTLPTEETSPCSSRSSQSYRHYSDHWEDERLESRRH | ||||||
Compositional bias | 1057-1090 | Polar residues | ||||
Sequence: FPRNRLQSVVVVPKNSTLPTEETSPCSSRSSQSY | ||||||
Compositional bias | 1091-1107 | Basic and acidic residues | ||||
Sequence: RHYSDHWEDERLESRRH | ||||||
Region | 1158-1233 | Disordered | ||||
Sequence: HPQSDGVDSTSHTDVKSDFLGHPNSEETAKAKIASRQQEELPVYSSDDFEDIPNKSRQQTIFPNRPDSRLGKTELS | ||||||
Compositional bias | 1160-1175 | Polar residues | ||||
Sequence: QSDGVDSTSHTDVKSD | ||||||
Compositional bias | 1212-1233 | Polar residues | ||||
Sequence: KSRQQTIFPNRPDSRLGKTELS | ||||||
Region | 1295-1319 | Disordered | ||||
Sequence: RNYWQGNGYWDPRSAGRPPGTGVVY | ||||||
Region | 1325-1344 | Disordered | ||||
Sequence: QVPDSLTDDREEEDSWDQCA | ||||||
Region | 1382-1423 | Disordered | ||||
Sequence: VNEKKDLSKNLEKNDMKDRGPPKKRRPELESDSESDGELQDR | ||||||
Domain | 1493-1547 | AWS | ||||
Sequence: IKRMQCECAPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQ | ||||||
Domain | 1549-1666 | SET | ||||
Sequence: ADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQ | ||||||
Domain | 1673-1689 | Post-SET | ||||
Sequence: EAQKCFCGSANCRGYLG | ||||||
Compositional bias | 1832-1866 | Polar residues | ||||
Sequence: AIPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTE | ||||||
Region | 1832-1871 | Disordered | ||||
Sequence: AIPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDT | ||||||
Region | 1917-1936 | Disordered | ||||
Sequence: EDEEELQSQQLLTQQLPESK | ||||||
Compositional bias | 1922-1936 | Polar residues | ||||
Sequence: LQSQQLLTQQLPESK | ||||||
Region | 1942-2006 | Disordered | ||||
Sequence: AMEASKLPISEPEADAEIEPKEGNGTKLEETIAEETPSQDEEEGVSDVESERSQEQPDKTVDISD | ||||||
Compositional bias | 1951-1970 | Basic and acidic residues | ||||
Sequence: SEPEADAEIEPKEGNGTKLE | ||||||
Compositional bias | 2018-2045 | Basic and acidic residues | ||||
Sequence: LKEVYRIPKKSQTEKENTITERGRDAVG | ||||||
Region | 2018-2147 | Disordered | ||||
Sequence: LKEVYRIPKKSQTEKENTITERGRDAVGFRDQTAAPKTPNRSRERDPDKQTQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTS | ||||||
Compositional bias | 2054-2079 | Basic and acidic residues | ||||
Sequence: KTPNRSRERDPDKQTQNKEKRKRRGS | ||||||
Compositional bias | 2089-2129 | Basic and acidic residues | ||||
Sequence: RGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVA | ||||||
Compositional bias | 2130-2147 | Polar residues | ||||
Sequence: QREAQKQQQQMQNLGMTS | ||||||
Domain | 2388-2421 | WW | ||||
Sequence: IVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTW | ||||||
Region | 2438-2464 | Disordered | ||||
Sequence: LGTPTYDENPMKTSKKPKTAEADTSSE | ||||||
Compositional bias | 2448-2464 | Basic and acidic residues | ||||
Sequence: MKTSKKPKTAEADTSSE |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,563
- Mass (Da)287,069
- Last updated2018-10-10 v2
- ChecksumCC398479DB1F1F70
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I2UMB5 | A0A2I2UMB5_FELCA | SETD2 | 2519 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Pro residues | ||||
Sequence: MKQLPPQPPPKMGDFY | ||||||
Compositional bias | 185-213 | Pro residues | ||||
Sequence: SPPSSPPPPPPPPQATTPSPAPVTEPVAL | ||||||
Compositional bias | 238-272 | Polar residues | ||||
Sequence: VTTVPESSDVDTKQDAVSNSSEEHITQNLNEQADT | ||||||
Compositional bias | 273-292 | Basic and acidic residues | ||||
Sequence: PSQKEDSHIGKEEEIPDSSK | ||||||
Compositional bias | 293-322 | Polar residues | ||||
Sequence: SNLGSKKTGSKKKSSQSEGTFLASESDEDS | ||||||
Compositional bias | 335-406 | Basic and acidic residues | ||||
Sequence: KFSASIEKERDSKKSLAPLKSEDLGKSSRSKTERDDKYFSYSKLERDTRYISSRCRSERERRRSRSRSRSDR | ||||||
Compositional bias | 419-466 | Basic and acidic residues | ||||
Sequence: RSHYYDSDRRYHRSSPYRERARYSRPYTDNRARESSDSEEEYKKTYSR | ||||||
Compositional bias | 467-481 | Polar residues | ||||
Sequence: RTSSHSFSYRDLRTS | ||||||
Compositional bias | 482-522 | Basic and acidic residues | ||||
Sequence: SSYSKSDRDCKTESSYLEMEKRGKYSSKVERESKRTSENEA | ||||||
Compositional bias | 963-990 | Basic and acidic residues | ||||
Sequence: SSIVLERRGRSEISLDEEGGRGHAHTSD | ||||||
Compositional bias | 1057-1090 | Polar residues | ||||
Sequence: FPRNRLQSVVVVPKNSTLPTEETSPCSSRSSQSY | ||||||
Compositional bias | 1091-1107 | Basic and acidic residues | ||||
Sequence: RHYSDHWEDERLESRRH | ||||||
Compositional bias | 1160-1175 | Polar residues | ||||
Sequence: QSDGVDSTSHTDVKSD | ||||||
Compositional bias | 1212-1233 | Polar residues | ||||
Sequence: KSRQQTIFPNRPDSRLGKTELS | ||||||
Compositional bias | 1832-1866 | Polar residues | ||||
Sequence: AIPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTE | ||||||
Compositional bias | 1922-1936 | Polar residues | ||||
Sequence: LQSQQLLTQQLPESK | ||||||
Compositional bias | 1951-1970 | Basic and acidic residues | ||||
Sequence: SEPEADAEIEPKEGNGTKLE | ||||||
Compositional bias | 2018-2045 | Basic and acidic residues | ||||
Sequence: LKEVYRIPKKSQTEKENTITERGRDAVG | ||||||
Compositional bias | 2054-2079 | Basic and acidic residues | ||||
Sequence: KTPNRSRERDPDKQTQNKEKRKRRGS | ||||||
Compositional bias | 2089-2129 | Basic and acidic residues | ||||
Sequence: RGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVA | ||||||
Compositional bias | 2130-2147 | Polar residues | ||||
Sequence: QREAQKQQQQMQNLGMTS | ||||||
Compositional bias | 2448-2464 | Basic and acidic residues | ||||
Sequence: MKTSKKPKTAEADTSSE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AANG04000016 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |