A0A2I1L8C1 · A0A2I1L8C1_9LACT
- ProteinBeta-ketoacyl-[acyl-carrier-protein] synthase III
- GenefabH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Catalytic activity
- malonyl-[ACP] + acetyl-CoA + H+ = 3-oxobutanoyl-[ACP] + CO2 + CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 109 | ||||
Active site | 247 | ||||
Active site | 277 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | beta-ketoacyl-acyl-carrier-protein synthase III activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-ketoacyl-[acyl-carrier-protein] synthase III
- EC number
- Short namesBeta-ketoacyl-ACP synthase III ; KAS III
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Aerococcaceae > Aerococcus
Accessions
- Primary accessionA0A2I1L8C1
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 248-252 | ACP-binding | |||
Domain
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence similarities
Belongs to the thiolase-like superfamily. FabH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)34,622
- Last updated2018-02-28 v1
- MD5 Checksum7F25D4594A8A76936FDFCF208971E84E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
QMHM01000002 EMBL· GenBank· DDBJ | RAV81127.1 EMBL· GenBank· DDBJ | Genomic DNA |