A0A2I1GZQ5 · A0A2I1GZQ5_9GLOM

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      RhiirA4_408032

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A4
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Glomeromycotina > Glomeromycetes > Glomerales > Glomeraceae > Rhizophagus

Accessions

  • Primary accession
    A0A2I1GZQ5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane142-161Helical
Transmembrane168-192Helical
Transmembrane236-258Helical
Transmembrane285-307Helical
Transmembrane327-350Helical
Transmembrane357-376Helical
Transmembrane382-402Helical
Transmembrane414-433Helical
Transmembrane453-473Helical
Transmembrane508-531Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-36Polar residues
Region1-41Disordered
Domain76-476Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    532
  • Mass (Da)
    59,437
  • Last updated
    2018-02-28 v1
  • Checksum
    7728732009FA9E82
MTSTEPLLSLSQRRPSLYSSSNGSAYEAIPTRSSLSSELPEERRLSFDSDYEDNESHKASLEEVTYEEERPWKYKLIALLCVLSLSVGSHYAAHTLGALKSIVKKELGISNSQYGVLQSSVSLVNTILPILGGVFIDIFGTSIGSILATSLIAIGSVFVAISTNLRSFVVMVIGRFLYGIGSGTIVTVQMAILSHWFKGKGLAIVVGIQVAASRMSSFLGNLTVVPIWERTGFYGWAFWFSAFLCIVSLIINITYILLMRILHDKLSQQEMMKIKQKKHFSPKKVLVFPTIYWIFVLLEILLGSAWTSFLHIHTELIKTRWNSTDEYAAYTSSIAQFLPIFISPFLGYFLDRFGNRSLTIIASSVFLTISMYLIGFVELSPIIIVTGMICFSISLSLGPVGLLSSIPILLPLDYVGTALGIVKSSLNIGSTIYDILVGLLQDLEGGKYGMVMSFYLGSSICAILVSILLYSVAKNWRDGILDMKDDERKRKHDTVKVEEFNQPTRKNYFYIITFIVLLIVSWILFFFKFFID

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-36Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LLXI01001139
EMBL· GenBank· DDBJ
PKY52108.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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