A0A2I1D2N1 · UNGD_ASPC2

Function

function

Hydrolase; part of the gene cluster that mediates the biosynthesis of the unguisins, gamma-aminobutyric acid (GABA)-containing fungal cyclic heptapeptides with the amino acid sequence cyclo-(D-Ala1-D-Val2-L-Leu3-beta-MePhe4-D-Ala5-D-Trp6-GABA7) for unguisin H and cyclo-(D-Ala1-D-Ala2-L-Leu3-beta-MePhe4-D-Ala5-D-Trp6-GABA7) for unguisin I (PubMed:36715406).
Within the pathway, the hydrolase ungD' catalyzes the hydrolysis between the D-tryptophan and GABA residues of unguisins H and I to produce the corresponding linear peptides (Probable). The alanine racemase ungC' catalyzes the interconversion of L-alanine and D-alanine, providing the D-alanine which is accepted by the first adenylation domain of the nonribosomal peptide synthetase (NRPS) ungA', whereas the methyltransferase ungE' provides the (2R,3R)-beta-methylphenylalanine residue incorporated by the module 4 (Probable). UngA' is the main enzyme within the cluster which condenses the 7 residues using its respective 7 modules (Probable). The terminal condensation domain (Ct) is involved in cyclization with D-alanine and thereby releasing of unguisins H and I (Probable)

Pathway

Secondary metabolite biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionhydrolase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Unguisins hydrolase ungD'
  • EC number
  • Alternative names
    • Unguisins biosynthesis cluster protein D'

Gene names

    • Name
      ungD'
    • ORF names
      P168DRAFT_297054

Organism names

  • Taxonomic identifier
  • Strain
    • IBT 28561
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati

Accessions

  • Primary accession
    A0A2I1D2N1

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004589131-534Unguisins hydrolase ungD'

Family & Domains

Sequence similarities

Belongs to the peptidase S12 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    534
  • Mass (Da)
    59,848
  • Last updated
    2018-02-28 v1
  • Checksum
    B8DD49F268A8B2D3
MISKTEDSGDPLDQDFAEVVKQTLDRWHIPGMSVAVVDGPDTWTKGYGLAQLPNTNVTPDTLFYTGSTTKAFTAAVLSLLVDDNKNYPQVQWNTPVNQLLRDDFVLSHEWDTNNITIEDILSHRTGMPRHEFAFGGDYDGHPASLRDIVRSVRYMQRSAPPRTTYQYSNLMFIVASYLIETLTGKWIGDVFREKIWRPLGMDSTYLSLEDARASGKELAQGYLYNSSLPGYEPVPLKNKPEVSGAGAAISNIKDYAKWATALLKRAPDVLSPAGYSAIWSARTVTPTHDPFITPSAYALAWNTQVYQGVEIVWHDGGIDGFGTEIALIPSLGFAVVTQANTTYSSNYAGTALVYHLIDKKLDVAPDKRFDWNKWYEDLERQMKEAVKNARQTFYPTVPSPAPPPTLPIGKYTGNYWHPAYRQLTILWDEERNLLYADRKDSTTPCQLTFIPVSREFFLVRLTVVGAEAMLPAEFRLGPDGTPSMVGILWEPSLGDEKIWLKKEGDTHFKEMYGGIVDSTAGKKRVPDTIHPIDL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MSFM01000006
EMBL· GenBank· DDBJ
PKY04127.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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