A0A2I0XD80 · A0A2I0XD80_9ASPA
- ProteinSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 82-84 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GRG | ||||||
Binding site | 142 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 234 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 248 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 299 | substrate; ligand shared with subunit alpha | ||||
Sequence: N | ||||||
Binding site | 356-358 | substrate; ligand shared with subunit alpha | ||||
Sequence: GIM |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Biological Process | succinyl-CoA metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Orchidaceae > Epidendroideae > Malaxideae > Dendrobiinae > Dendrobium
Accessions
- Primary accessionA0A2I0XD80
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-262 | ATP-grasp | ||||
Sequence: AELMSKYGINVPKGVAVSSVDEVKQALKNVFPQKKELVVKSQILAGGRGLGTFKSGLKGGVHIVKVEEVENIAGKMLGQILVTKQTGPQGKIVSKVYLCEKLSLVNEMYFAITLDRSSAGPLIIACRKGGTSIEDLAEKFPDMIIKVPIDVFKGITDEDAAKVVDGLAPKVADRNASIEQVKKLYELFCKSDCTLLEINPIAETSDNQLVAADAKLNFDDNAAFRQK |
Sequence similarities
Belongs to the succinate/malate CoA ligase beta subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)45,129
- Last updated2018-02-28 v1
- ChecksumEAFEC1166FEA51AE
Keywords
- Technical term