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A0A2I0X8V1 · A0A2I0X8V1_9ASPA

  • Protein
    Nicotinate phosphoribosyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.

Catalytic activity

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycosyltransferase activity
Molecular Functionnicotinate phosphoribosyltransferase activity
Biological ProcessNAD salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nicotinate phosphoribosyltransferase
  • EC number

Gene names

    • ORF names
      MA16_Dca002856

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Orchidaceae > Epidendroideae > Malaxideae > Dendrobiinae > Dendrobium

Accessions

  • Primary accession
    A0A2I0X8V1

Proteomes

Subcellular Location

PTM/Processing

Post-translational modification

Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-152Nicotinate phosphoribosyltransferase N-terminal
Domain431-542Nicotinate phosphoribosyltransferase C-terminal

Sequence similarities

Belongs to the NAPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    557
  • Mass (Da)
    62,096
  • Last updated
    2018-02-28 v1
  • MD5 Checksum
    21874D254A1D33DC00922A31CE8D6922
MESMAEANESAAASIPAATNPMVTPLLTDQYQYTMAYAYWKAGKHRERAVFDLFFRKSPFGGEYTVFGGLEECIRFVANFKLEDEEISFLQSVMPRCEDGFFEFLRQIDCSDVEVYAIPEGSVVFPKVPLMRVEGPVAVVQLLETPFVNLVNFASLVATNAARHRLVAGNSKTLLEFGLRRAQGPDGGVSASKYCYIGGFDATSNVAAGKLFGIPLRGTHSHAFVSSFTSLNEIVSRALQCRDGTSTCKDFVNLVQTWLNKLQHAVSLRGLTGATNESELAAFISYALAFPHNFLALVDTYNVMRSGLPNFCAVALALNDLGYKASGIRLDSGDLSYLSIESRKFFNAIEKEFCIAGFGKTAIAASNDLNEETLDALNKQGHEIDTYGIGTHLVTCYSQAALGCVFKLVEINNQPRMKLSEDITKVSIPCKKRCFRLYGREGFPLVDLMIGVNEPPPMAGDRILCRHPFIESKRAYVVPQHVEELLKCYWPGKSHETREELPSLQDIRNHCMQQLQKMRSDHMRRINPTPYKISVSGRLYDFIHFLWLNEAPVGELQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ502052
EMBL· GenBank· DDBJ
PKU84343.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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