A0A2I0X8V1 · A0A2I0X8V1_9ASPA
- ProteinNicotinate phosphoribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids557 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
Catalytic activity
- nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | nicotinate phosphoribosyltransferase activity | |
Biological Process | NAD salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinate phosphoribosyltransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Asparagales > Orchidaceae > Epidendroideae > Malaxideae > Dendrobiinae > Dendrobium
Accessions
- Primary accessionA0A2I0X8V1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Post-translational modification
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 26-152 | Nicotinate phosphoribosyltransferase N-terminal | |||
Domain | 431-542 | Nicotinate phosphoribosyltransferase C-terminal | |||
Sequence similarities
Belongs to the NAPRTase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length557
- Mass (Da)62,096
- Last updated2018-02-28 v1
- MD5 Checksum21874D254A1D33DC00922A31CE8D6922
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KZ502052 EMBL· GenBank· DDBJ | PKU84343.1 EMBL· GenBank· DDBJ | Genomic DNA |