A0A2I0UQB5 · A0A2I0UQB5_LIMLA

  • Protein
    S-adenosylmethionine decarboxylase proenzyme
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.

Catalytic activity

Cofactor

pyruvate (UniProtKB | Rhea| CHEBI:15361 )

Note: Binds 1 pyruvoyl group covalently per subunit.

Pathway

Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.

Features

Showing features for site, active site.

Type
IDPosition(s)Description
Site84-85Cleavage (non-hydrolytic); by autolysis
Active site85Schiff-base intermediate with substrate; via pyruvic acid
Active site99Proton donor; for catalytic activity
Active site282Proton acceptor; for processing activity
Active site296Proton acceptor; for processing activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionadenosylmethionine decarboxylase activity
Biological Processspermidine biosynthetic process
Biological Processspermine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine decarboxylase proenzyme
  • EC number

Gene names

    • ORF names
      llap_1429

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Limosa

Accessions

  • Primary accession
    A0A2I0UQB5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_50423231521-84S-adenosylmethionine decarboxylase beta chain
Modified residue85Pyruvic acid (Ser); by autocatalysis
ChainPRO_504232315185-387S-adenosylmethionine decarboxylase alpha chain

Keywords

Family & Domains

Sequence similarities

Belongs to the eukaryotic AdoMetDC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    387
  • Mass (Da)
    44,587
  • Last updated
    2018-02-28 v1
  • Checksum
    9E8436CDCCD72931
MLETSVATLLTLVSSQLPCPSGTAPLRRQLRQGIEFDSMVWVGICLINSSLLMRIEWDKLLENVHCLIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYSGFDSIQVECQKLLHLLRMVKEFHVHVGSAKVTDVFLWKTNLESFFYSRKNFMKPSHQEYPHRNFQEEVEFLNEIFPNGAAYCMGRMNSDCWYLYTLDFPESRISNQPDQTLEILMSELDPVVMDQFYMKDGVTANDVTRMSGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNISQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVFSSAQKIEGFKRLDHQIAQFSDYNFVFTSFTKNRQQQHS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ505657
EMBL· GenBank· DDBJ
PKU48235.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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