A0A2I0UQB5 · A0A2I0UQB5_LIMLA
- ProteinS-adenosylmethionine decarboxylase proenzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids387 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Catalytic activity
- S-adenosyl-L-methionine + H+ = S-adenosyl 3-(methylsulfanyl)propylamine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 84-85 | Cleavage (non-hydrolytic); by autolysis | |||
Active site | 85 | Schiff-base intermediate with substrate; via pyruvic acid | |||
Active site | 99 | Proton donor; for catalytic activity | |||
Active site | 282 | Proton acceptor; for processing activity | |||
Active site | 296 | Proton acceptor; for processing activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylmethionine decarboxylase activity | |
Biological Process | spermidine biosynthetic process | |
Biological Process | spermine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine decarboxylase proenzyme
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Limosa
Accessions
- Primary accessionA0A2I0UQB5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5042323152 | 1-84 | S-adenosylmethionine decarboxylase beta chain | ||
Modified residue | 85 | Pyruvic acid (Ser); by autocatalysis | |||
Chain | PRO_5042323151 | 85-387 | S-adenosylmethionine decarboxylase alpha chain | ||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length387
- Mass (Da)44,587
- Last updated2018-02-28 v1
- Checksum9E8436CDCCD72931
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KZ505657 EMBL· GenBank· DDBJ | PKU48235.1 EMBL· GenBank· DDBJ | Genomic DNA |