A0A2I0UGJ7 · A0A2I0UGJ7_LIMLA
- ProteinATP-dependent helicase ATRX
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2522 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nucleus | |
Cellular Component | pericentric heterochromatin | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent chromatin remodeler activity | |
Molecular Function | chromatin DNA binding | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | methylated histone binding | |
Biological Process | DNA repair | |
Biological Process | protein glycosylation | |
Biological Process | regulation of macromolecule metabolic process | |
Biological Process | replication fork processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase ATRX
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Scolopacidae > Limosa
Accessions
- Primary accessionA0A2I0UGJ7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 179-198 | Helical | ||||
Sequence: YAGPLMLGLLLAVVGGLVYL | ||||||
Transmembrane | 210-229 | Helical | ||||
Sequence: TGWAFAALCFVLAMTSGQMW | ||||||
Transmembrane | 264-286 | Helical | ||||
Sequence: IVLLFIMCIAGIGLVVLFFSWLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MAALPGLALLLLLAWGGSPAAG | ||||||
Chain | PRO_5014161276 | 23-2522 | ATP-dependent helicase ATRX | |||
Sequence: QKRKEMVLSEKVNQLMEWASKRSVIRMNGDKFRRLVKAPPRNYSVIVMFTALQPHRQCVVCKQADEEYQILANSWRYSSAFTNKIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFAAEQLARWVADRTDVNIRVIRPPNYAGPLMLGLLLAVVGGLVYLRGSNLDFLYNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGQVNYIHGSSQAQFVAETHIVLLFIMCIAGIGLVVLFFSWLLSVFRSKYHGYPYSESKLNTLVQKLHDFLAQSSEESEDANSPPALSKNKTIGKSREPRSSPASMENNREEGSSSSERSKSLGSSRSKRKPTVVTKYVGSDDEQALDETVNEDISNENSENDVDMKSLPKGTVVVQPEPVLNEDKDDFKGPEFRSRNTVKMKPEAPKKRGEEGLHGIVSCTACGQQVNHFQKDSIYRHPTLKVLICKTCYKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTILDENNQWHCYICHPEPLLDLVTACDSVFENLEQLLQQNKKKIKVESEKSKIYDHTVKFSPKRNNSNCNGEEKKLDDSHSGSLTYSYKALMVPKDLLKKTKKLVETTANLNSSFVSFLKNAAENVEISPTVQLCQLKAFKSVLSDMKKAHLALEEGLNLEIQALNVKIKDKNTKEKKTDVRSEKNEVKKDEGKEHVALKEDNTVKTQKKVVSERPDSKPMDQSVPTVEQADNKRTSGEDKSSGRNDEPQYEPNSTEALDMDIVSIPSSVPEDIFETLESAMEIQIASDETDNGNTGTDHETLNSNTKLNTPMKDTKESTVKAEDQDGNLEKGSEDAGVVSSAQKCDSVKQNRNAGSELSTENETVSLAEESDLRRSPRVKTTPLRRQADISPLTSNSEEDSNDTCNEKRKRKSSKQPSRKNDKRNSSDSTVDGPSPNKLCKSKKPYVVDQSSDSDEMPAVLKEVAMMSHSSSDIDSNSEAPANDQKTLNFLENSPVKDENGKRKRKSSSSGSDLDAKRGKSAKNSAAAKKKRQNYSDSSNYDSELEKEIKILSKIESAKKAKKKYSRKEDSYDSSEEEQRKKGSAAKERTNTDLKEITVKREHDESSDAEKSLLEKEESCPKDRLKNKKGSESKTKKSEKLKKKSYKKEQDDSSSDVEKSSPEKGEESFSEDTVRSKKQTEKKEKKKISHKKKIKKEQNDSSSSDEESYEDTKKKIKRGSMKESKKSNLKKKNSTGFCQSSGDEGETKSRAVPMEEEEDDDDDDPENRIAKKMLLEEIKANLSSDEDASSDDESDEGKKKTGKQNENTGDDEGNEKEDNSESDLEEEEEKESKKPRYRHRLLRHKLTVSDGESGEEKKVKPKEKKEGKRRNRRKVRSDDSNDSEFHESAVSEEVSESEDDQRPRTRSAKKAEVEENQRSYKQKKKRRRIKVQEDSSSENNNKSNSEDEDNDDSKSPGKGRKKIRKIIKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPLKCPITTKLVLDEDEETKEPLVQVHRSIVTRLKPHQVDGVQFMWDCCCESVKKTKTSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFRTALVVCPLNTALNWLNEFEKWQEGLEDDERLEVCELATVKRPQERSYMLQHWQDEGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTLVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKYEYVLEVRMTPIQCKLYQYYLDHLTGVGSGNEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYAKKKKSKGKKVKKEHSSGGSGSDNDVEVIKVWNSRSRGGGEGNAEELANNSPSVTKSDEGKATSSSNPDSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEELGDKVLVFSQSLISLDLIEDFLELANREKTDKDKPPIYKGEGKWFRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQSKPVFVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQINKEYIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNMPSGTNVLPANFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAARIQPLEDIISTIWKENVTLTESQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMSYQQAAMSHLMMPKPPNLIMNPSNYQQIDMRGMYQSVSGGMQPPPLQRAPPPVRGKSPGPSQKSM |
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 317-333 | Polar residues | ||||
Sequence: SSEESEDANSPPALSKN | ||||||
Region | 317-409 | Disordered | ||||
Sequence: SSEESEDANSPPALSKNKTIGKSREPRSSPASMENNREEGSSSSERSKSLGSSRSKRKPTVVTKYVGSDDEQALDETVNEDISNENSENDVDM | ||||||
Compositional bias | 340-354 | Polar residues | ||||
Sequence: REPRSSPASMENNRE | ||||||
Compositional bias | 361-375 | Polar residues | ||||
Sequence: ERSKSLGSSRSKRKP | ||||||
Domain | 452-589 | PHD-type | ||||
Sequence: KRGEEGLHGIVSCTACGQQVNHFQKDSIYRHPTLKVLICKTCYKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTILDENNQWHCYICHPEPLLDLVTACDSVFENLEQLLQQNKK | ||||||
Compositional bias | 720-764 | Basic and acidic residues | ||||
Sequence: NTKEKKTDVRSEKNEVKKDEGKEHVALKEDNTVKTQKKVVSERPD | ||||||
Region | 720-1092 | Disordered | ||||
Sequence: NTKEKKTDVRSEKNEVKKDEGKEHVALKEDNTVKTQKKVVSERPDSKPMDQSVPTVEQADNKRTSGEDKSSGRNDEPQYEPNSTEALDMDIVSIPSSVPEDIFETLESAMEIQIASDETDNGNTGTDHETLNSNTKLNTPMKDTKESTVKAEDQDGNLEKGSEDAGVVSSAQKCDSVKQNRNAGSELSTENETVSLAEESDLRRSPRVKTTPLRRQADISPLTSNSEEDSNDTCNEKRKRKSSKQPSRKNDKRNSSDSTVDGPSPNKLCKSKKPYVVDQSSDSDEMPAVLKEVAMMSHSSSDIDSNSEAPANDQKTLNFLENSPVKDENGKRKRKSSSSGSDLDAKRGKSAKNSAAAKKKRQNYSDSSNYDSE | ||||||
Compositional bias | 780-794 | Basic and acidic residues | ||||
Sequence: NKRTSGEDKSSGRND | ||||||
Compositional bias | 831-861 | Polar residues | ||||
Sequence: IQIASDETDNGNTGTDHETLNSNTKLNTPMK | ||||||
Compositional bias | 862-879 | Basic and acidic residues | ||||
Sequence: DTKESTVKAEDQDGNLEK | ||||||
Compositional bias | 891-914 | Polar residues | ||||
Sequence: QKCDSVKQNRNAGSELSTENETVS | ||||||
Compositional bias | 1017-1042 | Polar residues | ||||
Sequence: HSSSDIDSNSEAPANDQKTLNFLENS | ||||||
Compositional bias | 1044-1070 | Basic and acidic residues | ||||
Sequence: VKDENGKRKRKSSSSGSDLDAKRGKSA | ||||||
Compositional bias | 1104-1227 | Basic and acidic residues | ||||
Sequence: ESAKKAKKKYSRKEDSYDSSEEEQRKKGSAAKERTNTDLKEITVKREHDESSDAEKSLLEKEESCPKDRLKNKKGSESKTKKSEKLKKKSYKKEQDDSSSDVEKSSPEKGEESFSEDTVRSKKQ | ||||||
Region | 1104-1518 | Disordered | ||||
Sequence: ESAKKAKKKYSRKEDSYDSSEEEQRKKGSAAKERTNTDLKEITVKREHDESSDAEKSLLEKEESCPKDRLKNKKGSESKTKKSEKLKKKSYKKEQDDSSSDVEKSSPEKGEESFSEDTVRSKKQTEKKEKKKISHKKKIKKEQNDSSSSDEESYEDTKKKIKRGSMKESKKSNLKKKNSTGFCQSSGDEGETKSRAVPMEEEEDDDDDDPENRIAKKMLLEEIKANLSSDEDASSDDESDEGKKKTGKQNENTGDDEGNEKEDNSESDLEEEEEKESKKPRYRHRLLRHKLTVSDGESGEEKKVKPKEKKEGKRRNRRKVRSDDSNDSEFHESAVSEEVSESEDDQRPRTRSAKKAEVEENQRSYKQKKKRRRIKVQEDSSSENNNKSNSEDEDNDDSKSPGKGRKKIRKIIKDD | ||||||
Compositional bias | 1242-1278 | Basic and acidic residues | ||||
Sequence: IKKEQNDSSSSDEESYEDTKKKIKRGSMKESKKSNLK | ||||||
Compositional bias | 1279-1294 | Polar residues | ||||
Sequence: KKNSTGFCQSSGDEGE | ||||||
Compositional bias | 1313-1334 | Basic and acidic residues | ||||
Sequence: PENRIAKKMLLEEIKANLSSDE | ||||||
Compositional bias | 1341-1358 | Basic and acidic residues | ||||
Sequence: ESDEGKKKTGKQNENTGD | ||||||
Compositional bias | 1359-1374 | Acidic residues | ||||
Sequence: DEGNEKEDNSESDLEE | ||||||
Compositional bias | 1392-1410 | Basic and acidic residues | ||||
Sequence: HKLTVSDGESGEEKKVKPK | ||||||
Compositional bias | 1420-1468 | Basic and acidic residues | ||||
Sequence: RRKVRSDDSNDSEFHESAVSEEVSESEDDQRPRTRSAKKAEVEENQRSY | ||||||
Compositional bias | 1477-1506 | Basic and acidic residues | ||||
Sequence: IKVQEDSSSENNNKSNSEDEDNDDSKSPGK | ||||||
Coiled coil | 1521-1549 | |||||
Sequence: RTETQNALKEEEERRKRIAEREREREKLR | ||||||
Domain | 1612-1799 | Helicase ATP-binding | ||||
Sequence: KTKTSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFRTALVVCPLNTALNWLNEFEKWQEGLEDDERLEVCELATVKRPQERSYMLQHWQDEGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKEN | ||||||
Region | 1946-2033 | Disordered | ||||
Sequence: SDETSMSLSSDDYAKKKKSKGKKVKKEHSSGGSGSDNDVEVIKVWNSRSRGGGEGNAEELANNSPSVTKSDEGKATSSSNPDSPAPDW | ||||||
Compositional bias | 2004-2029 | Polar residues | ||||
Sequence: ELANNSPSVTKSDEGKATSSSNPDSP | ||||||
Domain | 2057-2236 | Helicase C-terminal | ||||
Sequence: EILRMAEELGDKVLVFSQSLISLDLIEDFLELANREKTDKDKPPIYKGEGKWFRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQSKPVFVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELT | ||||||
Region | 2492-2522 | Disordered | ||||
Sequence: QSVSGGMQPPPLQRAPPPVRGKSPGPSQKSM |
Sequence similarities
Belongs to the OST3/OST6 family.
Belongs to the SNF2/RAD54 helicase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,522
- Mass (Da)285,992
- Last updated2018-02-28 v1
- ChecksumC498407F390FB707
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 317-333 | Polar residues | ||||
Sequence: SSEESEDANSPPALSKN | ||||||
Compositional bias | 340-354 | Polar residues | ||||
Sequence: REPRSSPASMENNRE | ||||||
Compositional bias | 361-375 | Polar residues | ||||
Sequence: ERSKSLGSSRSKRKP | ||||||
Compositional bias | 720-764 | Basic and acidic residues | ||||
Sequence: NTKEKKTDVRSEKNEVKKDEGKEHVALKEDNTVKTQKKVVSERPD | ||||||
Compositional bias | 780-794 | Basic and acidic residues | ||||
Sequence: NKRTSGEDKSSGRND | ||||||
Compositional bias | 831-861 | Polar residues | ||||
Sequence: IQIASDETDNGNTGTDHETLNSNTKLNTPMK | ||||||
Compositional bias | 862-879 | Basic and acidic residues | ||||
Sequence: DTKESTVKAEDQDGNLEK | ||||||
Compositional bias | 891-914 | Polar residues | ||||
Sequence: QKCDSVKQNRNAGSELSTENETVS | ||||||
Compositional bias | 1017-1042 | Polar residues | ||||
Sequence: HSSSDIDSNSEAPANDQKTLNFLENS | ||||||
Compositional bias | 1044-1070 | Basic and acidic residues | ||||
Sequence: VKDENGKRKRKSSSSGSDLDAKRGKSA | ||||||
Compositional bias | 1104-1227 | Basic and acidic residues | ||||
Sequence: ESAKKAKKKYSRKEDSYDSSEEEQRKKGSAAKERTNTDLKEITVKREHDESSDAEKSLLEKEESCPKDRLKNKKGSESKTKKSEKLKKKSYKKEQDDSSSDVEKSSPEKGEESFSEDTVRSKKQ | ||||||
Compositional bias | 1242-1278 | Basic and acidic residues | ||||
Sequence: IKKEQNDSSSSDEESYEDTKKKIKRGSMKESKKSNLK | ||||||
Compositional bias | 1279-1294 | Polar residues | ||||
Sequence: KKNSTGFCQSSGDEGE | ||||||
Compositional bias | 1313-1334 | Basic and acidic residues | ||||
Sequence: PENRIAKKMLLEEIKANLSSDE | ||||||
Compositional bias | 1341-1358 | Basic and acidic residues | ||||
Sequence: ESDEGKKKTGKQNENTGD | ||||||
Compositional bias | 1359-1374 | Acidic residues | ||||
Sequence: DEGNEKEDNSESDLEE | ||||||
Compositional bias | 1392-1410 | Basic and acidic residues | ||||
Sequence: HKLTVSDGESGEEKKVKPK | ||||||
Compositional bias | 1420-1468 | Basic and acidic residues | ||||
Sequence: RRKVRSDDSNDSEFHESAVSEEVSESEDDQRPRTRSAKKAEVEENQRSY | ||||||
Compositional bias | 1477-1506 | Basic and acidic residues | ||||
Sequence: IKVQEDSSSENNNKSNSEDEDNDDSKSPGK | ||||||
Compositional bias | 2004-2029 | Polar residues | ||||
Sequence: ELANNSPSVTKSDEGKATSSSNPDSP |
Keywords
- Technical term