A0A2I0TZ98 · A0A2I0TZ98_LIMLA

  • Protein
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H+ + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O + indoxyl sulfate(in) = ADP + H+ + indoxyl sulfate(out) + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O + methotrexate(in) = ADP + H+ + methotrexate(out) + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O + pheophorbide a(in) = ADP + H+ + pheophorbide a(out) + phosphate
    This reaction proceeds in the forward direction.
  • ATP + H2O + riboflavin(in) = ADP + H+ + phosphate + riboflavin(out)
    This reaction proceeds in the forward direction.
  • ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H+ + phosphate + sphing-4-enine 1-phosphate(out)
    This reaction proceeds in the forward direction.
  • ATP + H2O + urate(in) = ADP + H+ + phosphate + urate(out)
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H+ + phosphate
    This reaction proceeds in the forward direction.
  • ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H+ + phosphate
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionABC-type xenobiotic transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionriboflavin transmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family G member 2
    • Urate exporter

Gene names

    • ORF names
      llap_10584

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Scolopacidae > Limosa

Accessions

  • Primary accession
    A0A2I0TZ98

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane420-440Helical
Transmembrane452-473Helical
Transmembrane503-521Helical
Transmembrane598-618Helical
Transmembrane686-704Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-55Disordered
Compositional bias28-55Polar residues
Domain60-309ABC transporter

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    711
  • Mass (Da)
    78,987
  • Last updated
    2018-02-28 v1
  • Checksum
    C08EF0817AFF215C
MVGVTAAHIPEPDPVNGQIRGTMAEGQPHLSIQMSDSNTNGISSRNQSSPDSASKGGSILTFHNVSYHVKMKTGFLCFQKTTHKEVLRNVNGIMRPGLNAILGPTGSGKSSLLDILAARKDPHGLSGDILINGAPQPANFKCTSGYVVQDDVVMGTLTVRENLKFSAALRLPKSVKEQEKNERVNEIINELGLSKVADSKVGTQFTRGVSGGERKRTNIGMELITDPAILFLDEPTTGLDASTANAVLLLLKRMAKQGKTIIFSIHQPRYSIFRLFDNLTLLAAGRVLYHGPAQDAIEYFQSVGYQCEPYNNPADFFLDIINGDSTAVAINKTDEANTVFSAEERTEYDTTLAEKLAERYCNAAYYQETKTALENISLGNTKKTKAIFRQITYANSFLHQLKWVSRRTFKNLIGNPQASIAQVCVTALLGLIVGAIFFGLKEDSSGLQNRVGAMFFLTTNQCFSSISAIELFVVEKKIFIHEYISGYYRTSVYFISKLMADLLPMRTLPSIIFTCIIYFMLGNEQTLKIAGTNFYNPSNVNLKTCPKQTIFLGFETNSRSLLYNDVYPYDGVLRSHFYGTSHCSRTERGRCGKPANDYHIFSGLLVNLTSVVSWLSWLQYFSIPRYGMTALQINELAGLNFCGSSNNTNLISNDNYQRISEMFCTGDEYLKKQGIDASSWGLWQNHLALACMTVIFLTIAYLKLRFMKKFS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias28-55Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ506572
EMBL· GenBank· DDBJ
PKU39105.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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