A0A2I0TZ98 · A0A2I0TZ98_LIMLA
- ProteinBroad substrate specificity ATP-binding cassette transporter ABCG2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids711 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + indoxyl sulfate(in) = ADP + H+ + indoxyl sulfate(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + methotrexate(in) = ADP + H+ + methotrexate(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + pheophorbide a(in) = ADP + H+ + pheophorbide a(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + riboflavin(in) = ADP + H+ + phosphate + riboflavin(out)This reaction proceeds in the forward direction.
- ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H+ + phosphate + sphing-4-enine 1-phosphate(out)This reaction proceeds in the forward direction.
- ATP + H2O + urate(in) = ADP + H+ + phosphate + urate(out)This reaction proceeds in the forward direction.
- ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H+ + phosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | efflux transmembrane transporter activity | |
Molecular Function | riboflavin transmembrane transporter activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBroad substrate specificity ATP-binding cassette transporter ABCG2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Scolopacidae > Limosa
Accessions
- Primary accessionA0A2I0TZ98
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 420-440 | Helical | ||||
Sequence: IAQVCVTALLGLIVGAIFFGL | ||||||
Transmembrane | 452-473 | Helical | ||||
Sequence: GAMFFLTTNQCFSSISAIELFV | ||||||
Transmembrane | 503-521 | Helical | ||||
Sequence: LPMRTLPSIIFTCIIYFML | ||||||
Transmembrane | 598-618 | Helical | ||||
Sequence: YHIFSGLLVNLTSVVSWLSWL | ||||||
Transmembrane | 686-704 | Helical | ||||
Sequence: HLALACMTVIFLTIAYLKL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-55 | Disordered | ||||
Sequence: MVGVTAAHIPEPDPVNGQIRGTMAEGQPHLSIQMSDSNTNGISSRNQSSPDSASK | ||||||
Compositional bias | 28-55 | Polar residues | ||||
Sequence: PHLSIQMSDSNTNGISSRNQSSPDSASK | ||||||
Domain | 60-309 | ABC transporter | ||||
Sequence: LTFHNVSYHVKMKTGFLCFQKTTHKEVLRNVNGIMRPGLNAILGPTGSGKSSLLDILAARKDPHGLSGDILINGAPQPANFKCTSGYVVQDDVVMGTLTVRENLKFSAALRLPKSVKEQEKNERVNEIINELGLSKVADSKVGTQFTRGVSGGERKRTNIGMELITDPAILFLDEPTTGLDASTANAVLLLLKRMAKQGKTIIFSIHQPRYSIFRLFDNLTLLAAGRVLYHGPAQDAIEYFQSVGYQCEP |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length711
- Mass (Da)78,987
- Last updated2018-02-28 v1
- ChecksumC08EF0817AFF215C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-55 | Polar residues | ||||
Sequence: PHLSIQMSDSNTNGISSRNQSSPDSASK |
Keywords
- Technical term